Table 3 Selected genes less expressed (log2 ≤ −1.0) during S. cerevisiae exposure to propolis according to the GO term finder enrichment analysis (for a complete list of the genes less expressed, see Additional file 1 : Table A1)
From: Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis
Cell cycle (GO:0007049) and Cell cycle process (GO: 0022402) (p< 4.76x10-6) | |
|---|---|
SMC4 | Subunit of the condensin complex; reorganizes chromosomes during cell division |
MCM10 | Essential chromatin-associated protein involved in the initiation of DNA replication |
CIN8 | Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation |
IBD2 | Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p |
BRN1 | Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus |
CEP3 | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere |
SLK19 | Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis |
NSL1 | Component of the MIND kinetochore complex which joins kinetochore subunits contacting DNA to those contacting microtubules |
SPC24 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex |
HOS2 | Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails |
ESA1 | Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 |
MAM1 | Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle |
Chromosome organization (GO:0051276) (p< 1.30x10 -6 ) | |
RLF2 | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) and Msi1p that assembles newly synthesized histones |
SGF29 | Probable subunit of SAGA histone acetyltransferase complex |
RNA metabolic process (GO:0016070) and RNA biosynthetic process (GO:0009058) (p< 0.02) | |
LEO1 | Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation |
SPT21 | Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2 |
RFM1 | Specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p |
IES2 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions |
IFH1 | IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loc |
NGG1 | component of transcriptional adaptor and histone acetyltransferase complexes, the ADA, the SAGA, and the SLIK complexes |