Table 2 Selected genes more expressed (log2 ≥ 1.0) during S. cerevisiae exposure to propolis according to the GO term finder enrichment analysis (for a complete list of the genes more expressed, see Additional file 1: Table A1)

FLR1

Multidrug transporter of the MFS, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs

PDR15

ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification

AZR1

Transporter of the MFS, involved in resistance to azole drugs such as ketoconazole and fluconazole

YOR1

ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin

PDR10

ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network

PDR12

ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance

ENA1

P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance

ENA2

P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux

VMA21

Membrane protein that is required for vacuolar H+−ATPase (V-ATPase) function, although not an actual component of the V-ATPase

TPO1

Polyamine transporter (MFS) that recognizes spermine, putrescine, and spermidine

TPO4

Polyamine transport protein (MFS) recognizes spermine, putrescine, and spermidine

ATG22

Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole

VMA7

Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+−ATPase (V-ATPase)

PKR1

V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase

Response to Stress (GO:0006950) and Response to Stimulus (GO:0050896) (p<0.009)

GRX4

Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase

GTT3

Protein of unknown function with a possible role in glutathione metabolism

TSA2

Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen

GTT2

Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p

GND2

6-phosphogluconate dehydrogenase, catalyzes an NADPH regenerating reaction in the pentose phosphate pathway

TRX1

Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress