From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Treatment | Sex | Hematological parameters | |||||||
---|---|---|---|---|---|---|---|---|---|
WBC (103/uL) | RBC(106/uL) | Hgb (%) | HCT (%) | MCV (fL) | MCH(pg) | MCHC(g/dl) | |||
Control (0.5% CMC) | M(n=5) | 11.28±3.69 | 6.73±1.21 | 13.52±1.93 | 33.54±6.88 | 48.94±1.46 | 21.10±2.30 | 43.84±5.80 | |
F (n=5) | 18.28±1.27 | 6.83±1.35 | 16.48±0.64 | 35.74±7.15 | 53.60±2.03 | 36.42±16.08 | 36.48±2.89 | ||
MF(n=10) | 15.97±2.01 | 6.39±0.89 | 14.85±1.11 | 33.01±4.81 | 50.81±1.53 | 29.30±8.00 | 39.95±4.46 | ||
NK | (300 mg/kg p.o/day) | M(n=5) | 12.12±2.39 | 6.10±0.99 | 13.02±1.88 | 30.92±5.18 | 50.80±0.75 | 21.82±1.66 | 43.28±3.57 |
F (n=5) | 13.50±1.89 | 7.69±0.77 | 14.10±1.20 | 38.80±3.62 | 49.70±1.32 | 19.48±0.65 | 36.681.84± | ||
MF(n=10) | 12.81±1.45 | 6.89±0.65 | 13.56±1.07 | 34.86±3.25 | 50.25±0.74 | 20.65±0.93 | 44.02±3.59 | ||
(600 mg/kg p.o/day) | M(n=5) | 12.68±2.39 | 6.54±0.29 | 13.20±0.82 | 33.40±1.24 | 48.54±4.69 | 19.76±0.72 | 44.82±4.15 | |
F (n=5) | 14.08±1.35 | 8.03±0.58 | 15.64±2.01 | 40.08±3.40 | 45.54±3.01 | 19.52±1.20 | 46.50±5.15 | ||
MF(n=10) | 13.38±1.32 | 7.28±0.40 | 14.42 ±1.10 | 36.74±2.04 | 47.04±2.68 | 19.64±0.66 | 45.43±4.26 | ||
(900mg/kg p.o/day) | M(n=5) | 17.36±1.26 | 6.68±1.40 | 15.40±1.51 | 30.96±7.05 | 48.54 ±2.18 | 22.10±2.08 | 42.46±2.51 | |
F (n=5) | 14.14±1.46 | 7.24±0.67 | 16.46±1.96 | 33.18±2.70 | 45.64±2.17 | 23.80±1.82 | 45.78±4.29 | ||
MF(n=10) | 15.75±1.05 | 6.96±0.74 | 15.93±1.18 | 32.07±3.58 | 47.09±1.53 | 22.95±1.33 | 44.12±2.41 | ||
Satellite group | |||||||||
Control (0.5% CMC) | M(n=5) | 18.18±2.30 | 8.67±0.55 | 18.48±0.90 | 42.82±1.73 | 47.08±1.97 | 19.48±0.57 | 40.94±2.13 | |
F (n=5) | 12.18±2.11 | 5.19±0.96 | 14.22±1.95 | 26.48±5.90 | 50.02±1.54 | 29.72±5.70 | 60.34±10.29 | ||
MF(n=10) | 15.18±1.78 | 6.93±0.78 | 16.35±1.24 | 34.65±3.98 | 48.55±1.28 | 24.60±3.20 | 50.64±6.71 | ||
NK (900 mg/kg p.o/day) | M(n=5) | 15.88±0.90 | 8.78±0.38 | 15.60±1.03 | 42.74±2.32 | 46.16±3.17 | 18.24±1.07 | 45.16±3.05 | |
F (n=5) | 8.84±1.26 | 6.63±1.14 | 14.42±2.22 | 33.46±6.08 | 50.10±0.77 | 23.30±1.67 | 42.36±3.60 | ||
MF(n=10) | 12.36±1.38 | 7.70±0.67 | 15.01±1.17 | 38.10±3.44 | 48.13±1.67 | 20.77±1.26 | 43.76±2.27 | ||
Treatment | Sex | Hematological parameters | |||||||
RDW-CV (%) | PLT (10 3 /uL) | MPV (fL) | PDW (%) | PCT (%) | P-LCR (%) | ||||
Control (0.5% CMC) | M(n=5) | 14.32±0.60 | 324.80±57.03 | 10.00±0.37 | 9.30±0.24 | 0.18±0.02 | 20.64±2.01 | ||
F (n=5) | 14.16±0.24 | 386.20±16.74 | 10.84±0.19 | 8.98±0.22 | 0.17±0.01 | 26.48±1.15 | |||
MF(n=10) | 14.15± 0.33 | 372.90± 36.83 | 10.68 ± 0.19 | 8.65 ± 0.25 | 0.17 ± 0.02 | 23.87 ± 1.22 | |||
NK | (300 mg/kg p.o/day) | M(n=5) | 13.70±0.54 | 351.00±45.03 | 10.34±0.78 | 9.02±0.60 | 0.11±0.01 | 20.08±2.83 | |
F (n=5) | 13.54±0.70 | 393.40±74.87 | 10.62±0.39 | 9.34±0.52 | 0.11±0.01 | 22.80±1.24 | |||
MF(n=10) | 13.62± 0.42 | 372.20± 41.79 | 10.48 ± 0.41 | 9.18± 0.38 | 0.11± 0.02 | 21.44± 1.53 | |||
(600 mg/kg p.o/day) | M(n=5) | 16.58±2.62 | 369.40±65.75 | 8.96±0.74 | 8.80±0.28 | 0.15±0.02 | 22.53±1.11 | ||
F (n=5) | 14.04±0.38 | 377.40±66.43 | 10.52±0.21 | 8.88±0.24 | 0.15±0.02 | 20.66±1.33 | |||
MF(n=10) | 15.31 ± 1.32 | 373.40± 44.08 | 9.71± 0.49 | 8.85± 0.19 | 0.15± 0.01 | 21.65± 1.62 | |||
(900mg/kg p.o/day) | M(n=5) | 13.46±1.10 | 378.00±4.32 | 8.56±1.39 | 9.56±0.39 | 0.13±0.03 | 19.98±1.30 | ||
F (n=5) | 14.90±0.57 | 366.00±60.78 | 10.640.87± | 8.30±0.63 | 0.16±0.02 | 20.22±1.57 | |||
MF(n=10) | 14.18± 0.63 | 372.00± 28.79 | 9.60± 0.85 | 8.93±0.41 | 0.15± 0.02 | 20.10± 0.96 | |||
Satellite group | |||||||||
Control (0.5% CMC) | M(n=5) | 14.08±0.56 | 377.20±46.72 | 10.76±0.19 | 8.32±0.40 | 0.15±0.02 | 22.54±1.31 | ||
F (n=5) | 13.86±0.89 | 369.20±29.87 | 10.44±0.42 | 8.70±0.22 | 0.20±0.08 | 25.18±1.51 | |||
MF(n=10) | 13.97± 0.50 | 373.20±26.17 | 10.60±0.22 | 8.51±0.22 | 0.17±0.04 | 23.86±1.04 | |||
NK (900 mg/kg p.o/day) | M(n=5) | 15.70±1.34 | 373.60±39.33 | 10.56±0.76 | 7.98±0.51 | 0.11±0.01 | 28.20±0.86 | ||
F (n=5) | 15.00±0.58 | 371.20±34.98 | 10.09±0.59 | 9.70±0.36 | 0.10±0.01 | 25.70±1.76 | |||
MF(n=10) | 15.35± 0.70 | 372.40±24.82 | 10.32±0.46 | 8.84±0.41 | 0.11±0.01 | 26.95±1.01 |