Table 12 Histopathological investigation of control and NK treated animals for 28 days
From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Tissue | Treatment | Male | Female |
|---|---|---|---|
Brain, Eyes | Control (0.5% CMC) | Normal | Normal |
NK (900 mg/kg p.o/day) | Normal | Normal | |
Satellite - NK (900 mg/kg p.o/day) | Normal | Normal | |
Lung (right and left), Prostate, Thyroid gland, Thymus | Control (0.5% CMC) | Normal | Normal |
NK (900 mg/kg p.o/day) | Normal | Normal | |
Satellite - NK (900 mg/kg p.o/day) | Normal | Normal | |
Spinal Cord, Lymph Nodes, Muscle, Bone | Control (0.5% CMC) | Normal | Normal |
NK (900 mg/kg p.o/day) | Normal | Normal | |
Satellite - NK (900 mg/kg p.o/day) | Normal | Normal | |
Heart, Liver | Control (0.5% CMC) | Normal | Normal |
NK (900 mg/kg p.o/day) | Normal | Normal | |
Satellite - NK (900 mg/kg p.o/day) | Normal | Normal | |
Stomach, Intestine | Control (0.5% CMC) | Normal | Normal |
NK (900 mg/kg p.o/day) | Normal | Normal | |
Satellite - NK (900 mg/kg p.o/day) | Normal | Normal | |
Kidney, Adrenals, Urinary bladder | Control (0.5% CMC) | Normal | Normal |
NK (900 mg/kg p.o/day) | Normal | Normal | |
Satellite - NK (900 mg/kg p.o/day) | Normal | Normal | |
Sex organ (Testis/Epididymis) | Control (0.5% CMC) | Normal | - |
NK (900 mg/kg p.o/day) | Normal | - | |
Satellite - NK (900 mg/kg p.o/day) | Normal | - | |
Sex organ (Uterus /ovaries/) | Control (0.5% CMC) | - | Normal |
NK (900 mg/kg p.o/day) | - | Normal | |
Satellite - NK (900 mg/kg p.o/day) | - | Normal |