Figure 10

Effects of CTS and THA treatment on diabetes-induced cholinergic neuron degeneration in the medial septum. Cholinergic neurons were identified by ChAT immunostaining in vehicle-treated m/m (1), and vehicle (2)-, CTS (750 mg/kg per day: 3)-, and THA (2.5 mg/kg per day; 4)-treated db/db mice. Cholinergic neurons were stained with anti-ChAT antibody, showing that predominant ChAT expression occurred in the cell body of cholinergic neurons. Scale bar = 100 μm.