Association of the UCP-1 single nucleotide polymorphism A-3826G with the dampness-phlegm pattern among Korean stroke patients

Table 3 The genotype distribution of UCP-1 polymorphisms in the dampness-phlegm and non-dampness-phlegm groups compared with the normal group

Model	SNPs	Genotype	Normal	Non-dampness	OR [95% CI]	p	Dampness	OR [95% CI]	p
Model	SNPs	Genotype	Normal	phlegm	OR [95% CI]	p	Phlegm	OR [95% CI]	p
Allele	A-3826G	A	619 (53.27)	1,032 (51.43)	1.097	0.2586	575 (49.57)	1.205	0.0443
		G	543 (46.73)	978 (48.66)	(0.934,1.290)		585 (50.43)	(1.005,1.444)
	A-1766G	A	871 (75.22)	1512 (75.6)	0.968	0.7371	873 (75.91)	0.98	0.8548
		G	287 (24.78)	488 (24.4)	(0.802,1.169)	0.7371	277 (24.09)	(0.793, 1.212)	0.8548
	Ala64Thr	A	77 (6.58)	130 (6.45)	0.984	0.9226	91 (7.84)	0.879	0.468
		G	1,093 (93.42)	1,886 (93.55)	(0.710,1.364)	0.9226	1,069 (91.67)	(0.621,1.245)	0.468
^†Do	A-3826G	AA	164 (28.23)	267 (26.57)	1.168	0.2319	129 (22.24)	1.508	0.0065
		AG+GG	417 (71.77)	738 (73.43)	(0.906,1.506)	0.2319	451 (77.76)	(1.122, 2.028)	0.0065
	A-1766G	AA	335 (57.86)	563 (56.3)	1.066	0.5872	328 (57.04)	1.023	0.8644
		AG+GG	244 (42.14)	437 (43.7)	(0.846,1.344)	0.5872	247 (42.96)	(0.789, 1.327)	0.8644
	Ala64Thr	GG	508 (86.84)	879 (87.2)	0.989	0.9489	492 (84.83)	1.087	0.6157
		GA+AA	77 (13.16)	129 (12.8)	(0.704,1.389)	0.9489	88 (15.17)	(0.762, 1.583)	0.6157
^†R	A-3826G	AA+AG	455 (78.31)	765 (76.12)	1.093	0.5257	446 (76.90)	1.092	0.5749
		GG	126 (21.69)	240 (23.38)	(0.831,1.437)	0.5257	134 (23.10)	(0.803,1.485)	0.5749
	A-1766G	AA+AG	536 (92.57)	949 (94.9)	0.606	0.0423	545 (94.78)	0.801	0.4183
		GG	43 (7.43)	51 (5.1)	(0.374, 0.983)	0.0423	30 (5.22)	(0.468,1.371)	0.4183
	Ala64Thr	GG+GA	585 (100)	1,007 (99.9)	ND	ND	577 (99.48)	ND	ND
		AA	0 (0)	1 (0.1)		ND	3 (0.52)		ND

* The values indicate the frequency of subjects (%). OR (95% CI) and Siga, Sigb value were calculated using a binary logistical regression model adjusted for sex, age, smoking, and drinking with normal versus non-dampness-phlegm, normal versus dampness-phlegm . † Do and R denote dominant and recessive models, respectively. CI: confidence interval. P-values with statistical significance were presented in bold (< 0. 05).

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