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Table 4 Percentage of different type of chromosomal damage induced by CDDP and reversed with cactus cladodes extract before or after treatment with CDDP

From: Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb/c mice: combination with phytochemical composition

Experimental groups

Centric fusion

Ring

Break

Gap

Total

H2O

1,5 ± 1,25

1,00 ± 0,43

3,28 ± 0,25

0 ± 0,00

3,78 ± 1,5

CCE

1,67 ± 0,75

1 ± 1,33

0 ± 0,00

1 ± 0,67

3,67 ± 1,78

CDDP 15 days

2,13 ± 0,28*

1 ± 0,17

10 ± 2,02*

2,13 ± 1,5*

15,26 ± 1,75*

CDDP + CCE Pre-treatment

1,66 ± 0,55*

0 ± 0,17

6 ± 1,68*

1 ± 0,24

8,66 ± 1,53*

CDDP + CCE Post-treatment

2,03 ± 1,5*

1 ± 0,33

7,3 ± 1,45*

0 ± 0,00

10,33 ± 2,06*

CDDP 30 days

5 ± 1,77*

2,66 ± 2,67*

20 ± 1,57*

5 ± 1,25*

32,66 ± 2,14*

CDDP + CCE Pre-treatment

3 ± 1,48*

1,33 ± 0,58*

5 ± 2,01*

1 ± 1,00*

10,33 ± 1,45*

CDDP + CCE Post-treatment

2 ± 1,78*

1 ± 0,25*

6 ± 0,05*

3,58 ± 1,45*

12,58 ± 1,67*

  1. (*) Significant compared with group 1(H2O) (P<0.05).