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Table 4 Percentage of different type of chromosomal damage induced by CDDP and reversed with cactus cladodes extract before or after treatment with CDDP

From: Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb/c mice: combination with phytochemical composition

Experimental groups Centric fusion Ring Break Gap Total
H2O 1,5 ± 1,25 1,00 ± 0,43 3,28 ± 0,25 0 ± 0,00 3,78 ± 1,5
CCE 1,67 ± 0,75 1 ± 1,33 0 ± 0,00 1 ± 0,67 3,67 ± 1,78
CDDP 15 days 2,13 ± 0,28* 1 ± 0,17 10 ± 2,02* 2,13 ± 1,5* 15,26 ± 1,75*
CDDP + CCE Pre-treatment 1,66 ± 0,55* 0 ± 0,17 6 ± 1,68* 1 ± 0,24 8,66 ± 1,53*
CDDP + CCE Post-treatment 2,03 ± 1,5* 1 ± 0,33 7,3 ± 1,45* 0 ± 0,00 10,33 ± 2,06*
CDDP 30 days 5 ± 1,77* 2,66 ± 2,67* 20 ± 1,57* 5 ± 1,25* 32,66 ± 2,14*
CDDP + CCE Pre-treatment 3 ± 1,48* 1,33 ± 0,58* 5 ± 2,01* 1 ± 1,00* 10,33 ± 1,45*
CDDP + CCE Post-treatment 2 ± 1,78* 1 ± 0,25* 6 ± 0,05* 3,58 ± 1,45* 12,58 ± 1,67*
  1. (*) Significant compared with group 1(H2O) (P<0.05).