Table 7 Effect of the methanolic extract of Phyllanthus muellerianus on different liver biochemical parameters of male and female rats
Dose (g/kg) | Sex | ALAT (UI/g of liver) | ASAT (UI/g of liver) | MDA (mmol/g of liver) | Glutathione (GSH) (μmol/g of liver) |
|---|---|---|---|---|---|
0 | Male | 74.60 ± 11.64 | 40.83 ± 0.18 | 10.00 ± 1.58 | 4.12 ± 1.11 |
|  | Female | 74.50 ± 10.00 | 42.00 ± 4.21 | 10.25 ± 2.04 | 4.62 ± 1.24 |
4 | Male | 71.66 ± 2.92 | 42.66 ± 2.37 | 12.50 ± 5.27 | 4.31 ± 2.23 |
|  | Female | 79.50 ± 2.15 | 40.28 ± 1.95 | 13.27 ± 4.52 | 4.48 ± 1.21 |
8 | Male | 79.36 ± 5.48* | 43.00 ± 1.82* | 16.25 ± 3.44* | 4.12 ± 1.11 |
|  | Female | 78.10 ± 4.21* | 43.12 ± 1.51* | 14.70 ± 4.21* | 4.62 ± 1.24 |
12 | Male | 61.00 ± 1.73* | 30.50 ± 1.82** | 24.00 ± 4.33** | 2.32 ± 1.25** |
|  | Female | 60.00 ± 3.10* | 30.01 ± 2.31** | 14.95 ± 3.12* | 3.16 ± 1.84* |
16 | Male | 44.33 ± 6.21** | 24.33 ± 13.14** | 26.15 ± 2.55** | 2.19 ± 1.23** |
|  | Female | 44.01 ± 3.57** | 23.98 ± 8.24** | 23.21 ± 5.11** | 3.02 ± 1.34* |
20 | Male | 22.33 ± 6.21** | 24.23 ± 10.14** | 45.25 ± 2.15** | 2.31 ± 1.13** |
|  | Female | 24.01 ± 3.57** | 22.68 ± 6.24** | 46.29 ± 5.21** | 2.22 ± 2.14** |