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Table 1 Baseline characteristics of the two study groups

From: Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study

Characteristic MSM (N = 25) Placebo (N = 25) p value*
Kellgren and Lawrence Grade
   Grade 1 4 8  
   Grade 2 7 6  
   Grade 3 4 6  
   Grade 4 10 5 0.324
Male gender 4 13 0.007*
Age 67.0 ± 9.8 71.0 ± 8.3 0.203
Body mass index (BMI) 31.4 ± 5.4 28.6 ± 3.09 0.037*
WOMAC (0-100 mm scale)
   Pain subscale 42.4 ± 25.7 45.9 ± 27.4 0.641
   Stiffness subscale 46.7 ± 24.8 43.0 ± 35.6 0.671
   Function subscale 39.9 ± 21.2 47.4 ± 21.9 0.221
   Aggregated total score 40.9 ± 20.3 47.0 ± 22.2 0.100
ALF (seconds)
   8 meter walk time 9.4 ± 3.9 8.2 ± 2.1 0.172
   Stand-sit-stand transfer time 10.4 ± 5.3 8.4 ± 2.4 0.106
   Stair ascent and descent time 23.9 ± 15.1 16.5 ± 5.8 0.029*
   ALF score 43.6 ± 23.2 33.1 ± 9.6 0.043*
SF-36 (0-100 scale)
   SF-36 score results 54.1 ± 18.9 58.0 ± 17.2 0.446
Visual-analogue-scale for pain 3.78 ± 3.04 4.60 ± 2.74 0.320
Knee Society Knee Score 60.04 ± 15.6 59.5 ± 17.1 0.911
Knee Society Function Score 60.4 ± 17.2 58.9 ± 13.1 0.734
  1. Values are presented as mean ± SD.
  2. * The significance threshold was set at p ≤ 0.05.
  3. MSM = methylsulfonylmethane; WOMAC = Western Ontario and McMaster Osteoarthritis Index; ALF = aggregated locomotor function; SF-36 = 36-item short-form health survey.
  4. There were significant differences between the groups at baseline in gender, BMI and ALF score. Results of the study were adjusted to account for these differences.