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Table 2 EGFR signals and apoptosis mediators

From: American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR

Protein

AOM/DSS

+ginseng

pEGFR

2.2 ± 0.3*

1.1 ± 0.2†

pErbB2

2.8 ± 0.4*

1.6 ± 0.1†

pERK

8.3 ± 0.1*

5.8 ± 0.3*,†

pAKT

7.2 ± 0.3*

4.4 ± 0.8*,†

Cox-2

3.1 ± 0.3*

1.9 ± 0.2*,†

PCNA

10.7 ± 1.2*

6.3 ± 0.1*,†

Bax

1.6 ± 0.3

2.0 ± 0.1*,†

Bcl2

1.1 ± 0.1

1.1 ± 0.2

c-Jun

1.2 ± 0.2

0.6 ± 0.2†

p27Kip1

1.0 ± 0.5

0.9 ± 0.1

p21Waf1

1.8 ± 0.2

3.8 ± 0.1*,†

CCND1

2.9 ± 0.6*

2.7 ± 0.4*

  1. *p < 0.05, compared to vehicle treated on WD; †p < 0.05 compared to AOM/DSS on WD; n = 4 tumors in each group.