Gene | CT a | IL-1β | IL-1β + RHP (250 mg/L) | IL-1β + GLGPG (9.7 mg/L) | ||
---|---|---|---|---|---|---|
 |  | fold change | fold change | p valueb | fold change | p valueb |
MMP-1 | 27.2 | 6.3 | 3.6 | 0.002 | 4.5 | 0.019 |
MMP-2 | 22.3 | 0.8 | 0.6 | 0.006 | 1.0 | 0.142 |
MMP-3 | 32.7 | 182.7 | 80.6 | < 0.001 | 137.0 | 0.003 |
MMP-9 | 31.8 | 6.3 | 7.1 | 0.285 | 10.7 | 0.001 |
MMP-13 | 28.4 | 17.7 | 8.9 | < 0.001 | 12.7 | 0.005 |
ADAMTS-4 | 35.3 | 10.7 | 9.8 | 0.136 | 9.6 | 0.026 |
ADAMTS-5 | 31.1 | 0.8 | 0.7 | 0.476 | 1.4 | 0.006 |
TIMP-1 | 21.2 | 1.4 | 1.2 | 0.195 | 1.9 | 0.007 |
Aggrecan | 32.0 | 1.8 | 1.3 | 0.017 | 3.7 | < 0.001 |
Collagen I | 19.2 | 1.1 | 0.8 | 0.028 | 1.8 | 0.001 |
COL2A1 | 31.9 | 0.8 | 0.6 | 0.001 | 0.9 | 0.526 |
MIP-2 | 40.2 | 1169 | 474 | < 0.001 | 1626 | 0.006 |
MIP-3α | 38.5 | 19642 | 12001 | < 0.001 | 20822 | 0.437 |
CCL5/RANTES | 42.9 | 35920 | 27081 | 0.048 | 41476 | 0.353 |
IL-8 | 34.5 | 12022 | 5599 | < 0.001 | 16308 | 0.001 |
CXCL10/IP-10 | 39.7 | 3274 | 836 | 0.001 | 1436 | 0.001 |
IL-1α | 37.7 | 42.3 | 29.9 | 0.036 | 32.0 | 0.065 |
IL-1β | 31.9 | 135.3 | 118.1 | 0.195 | 100.8 | 0.012 |
IL-6 | 38.4 | 10846 | 5969 | 0.001 | 8876 | 0.122 |
IL-1Ra | 31.9 | 1.1 | 1.4 | 0.381 | 1.7 | 0.111 |
IL-1RI | 27.1 | 1.7 | 0.9 | 0.001 | 1.7 | 0.885 |
TNF-α | 34.5 | 319.2 | 705.1 | 0.001 | 567.8 | 0.003 |
iNOS | 35.4 | 17.6 | 22.4 | 0.139 | 21.2 | 0.236 |
COX-2 | 34.4 | 23.4 | 19.0 | 0.080 | 35.3 | 0.005 |
LIF | 30.1 | 64.8 | 53.9 | 0.118 | 42.1 | 0.005 |