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Table 6 Minimal inhibitory concentration (MIC) of antibiotics in the absence and presence of the sub-inhibitory concentrations of B. cinnamomea extract (μg/ml) against some MDR bacteria.

From: Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes

Bacterial strains

Antibiotics and MIC in absence and presence B. cinnamomea extracts at MIC/2 and MIC/5

 

Chloramphenicol

Cloxacillin

Ampicillin

Erythromycin

Kanamycin

 

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

PA124

32

< 0, 5 (> 32) s

32 (1) s

-

-

-

-

-

-

64

8 (8) s

32 (2) s

32

32 (1)

64

CM64

256

-

-

-

-

-

-

-

-

-

64 (> 8) s

64 (> 8) s

1

< 0.5 (> 2) s

< 0.5 (> 2) s

EA3

-

16 (> 32) S

32

-

256

-

-

-

-

64

8 (8) s

32 (2) s

32

16 (2) s

16 (2) s

EA27

256

8 (32) s

16 (16) s

256

< 0, 5 (> 512) s

16(16) s

64

64 (1) I

64 (1) I

32

8 (4) s

32 (2) s

16

< 0.5 (> 32) s

16(1) I

EA289

-

256

-

-

-

-

-

-

-

256

32 (8) s

64 (4) s

4

4 (1) I

4 (1) I

KP55

64

8 (8) s

8 (8) s

-

-

-

-

-

-

256

128 (2) s

128 (2) s

32

32 (1) I

32 (1) I

AG100ATET

64

16 (4) s

32 (2) s

-

128 (> 4) S

128 (> 4) S

-

8 (> 64) S

32 (16) S

32

32 (1) I

32 (1) I

32

1 (32) s

8 (4) s

AG100

8

< 2 (> 4) s

4 (2) s

256

256 (1)

256 (1)

64

< 2(> 32) s

4 (16) s

32

< 2 (> 16) s

4 (8) s

< 2

< 2

< 2

Bacterial strains

Tetracycline

Cefepime

Streptomycin

Ciprofloxacin

Norfloxacin

 

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

PA124

4

2 (2) s

4 (1) s

-

64 (> 8) s

-

16

16 (1)

16 (1)

16

16 (1) I

16 (1) I

128

64 (2) s

64 (2) s

CM64

32

8 (4) s

8 (4) s

256

32 (8) s

32 (8) s

8

< 2 (> 4) s

< 2 (> 4) s

1

1 (1) I

1 (1) I

2

1 (2) s

2 (1) I

EA3

2

1 (2) s

2 (1) I

-

-

-

16

4 (4) s

4 (4) s

64

4 (16) s

8(8) s

64

16 (4) s

32 (2) s

EA27

16

1 (16) s

4 (4) s

256

16 (16) s

64(4) s

8

< 0.5 (> 16) s

2 (4) s

2

< 0.5 (> 4) s

2 (1) I

16

< 0.5 (> 32) s

4 (4) s

EA289

8

4 (2) s

4 (2) s

-

256 (> 2) s

256 (> 2) s

64

16 (4) s

64 (1) I

32

16 (2) s

16 (2) s

64

32 (2) s

32 (2) s

KP55

4

4 (1) I

4 (1) I

-

64 (> 8) s

128 (> 2) s

8

8 (1) I

8 (1) I

128

8 (16) s

16 (8) s

128

16 (8) s

32 (4) s

AG100ATET

4

2 (2) s

2 (2) s

-

256 (> 2) s

64(> 4) s

16

8 (2) s

16 (1) I

64

4 (16) s

8 (8) s

64

32 (2) s

64 (1) I

AG100

< 2

< 2

< 2

256

64 (4) s

64 (4) s

256

256 (1) I

256 (1) I

4

< 2 (> 2) s

< 2 (> 2) s

32

4 (8) s

32 (1) I

  1. MIC/2: concentration of plant extract added equal to 512 μg/ml for PA124, CM64, EA3, EA27, AG100; and to 256 μg/ml for EA289, KP55 and AG100ATET
  2. MIC/5: concentration of plant extract added equal to 204.8 μg/ml for PA124, CM64, EA3, EA27, KP55, AG100; and to102.4 μg/ml for EA289 and AG100ATET
  3. (): Values in bracket are folds increase of activity. S: synergy, I: indifference; (-): > 512 μg/ml