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Table 5 Minimal inhibitory concentration (MIC) in μg/ml of antibiotics in the absence and presence of the sub-inhibitory concentrations of D. glomerata extracts against MDR bacteria.

From: Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes

Bacterial strains

Antibiotics and MIC in absence and presence D. glomerata extracts at MIC/2 and MIC/5

 

Chloramphenicol

Cloxacillin

Ampicillin

Erythromycin

Kanamycin

 

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

PA124

32

32 (1) I

16 (2) s

-

-

-

64

-

-

64

32 (2) s

64 (1) I

64

16 (4) s

64 (1)

CM64

256

256 (1) I

-

-

-

-

-

-

256

-

64

128

1

1 (1) I

1(1) I

EA3

-

32 (> 16) s

32 (> 16) s

-

256

256

-

-

-

64

32 (2) s

64 (1) I

32

16 (2) s

16 (2) s

EA27

256

32 (8) s

64 (4) s

256

64 (4) s

64 (4) s

64

64 (1) I

64 (1) I

32

32 (1) I

32 (1) I

16

16 (1) I

16 (1) I

EA289

-

-

-

-

-

-

-

256

64

256

64 (4) s

128 (2) s

4

< 2 (> 2) s

4 (1) I

KP55

64

8 (8) s

16 (4) s

-

-

-

-

-

-

256

128 (2) s

128 (2) s

32

32 (1) I

32 (1) I

AG100ATET

64

8 (8) s

16 (4) s

-

-

-

-

16

32

32

32 (1) I

16 (2) s

32

2 (16) s

8 (4) s

AG100

8

< 2 (> 4) s

< 2 (> 4) s

256

128 (2) s

64 (4) s

64

4 (16) s

4 (16) s

32

< 2 (> 16) s

4 (8) s

< 2

< 2

< 2

Bacterial strains

Tetracycline

Cefepime

Streptomycin

Ciprofloxacin

Norfloxacin

 

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

Alone

MIC/2

MIC/5

PA124

4

< 0, 5 (> 8) s

2 (2) s

-

-

-

16

16 (1) I

16 (1) I

16

< 0, 5 (> 8) s

16 (1) I

128

-

-

CM64

32

4 (8) s

8 (4) s

256

64 (4) s

128 (2) s

8

< 2 (> 4) s

4 (2) s

1

1 (1) I

1 (1) I

2

1 (2) s

1 (2) s

EA3

2

1 (2) s

2 (2) s

-

-

-

16

8 (2) s

8 (2) s

64

4 (16) s

64 (1) I

64

32 (2) s

64 (1) I

EA27

16

4 (4) s

8 (2) s

256

128 (2) s

128 (2) s

8

4 (2) s

4 (2) s

2

2 (1) I

2 (1) I

16

2 (8) s

4 (4) s

EA289

8

1 (8) s

2 (4) s

-

256 (> 2) s

-

64

8 (8) s

32 (2) s

32

16 (2) s

16 (2) s

64

16 (4) s

32 (2) s

KP55

4

2 (2) s

2 (2) s

-

128 (> 4) s

-

8

8 (1) I

8 (1) I

128

4 (32) s

32 (4) s

128

32 (4) s

32 (4) s

AG100ATET

4

1 (4) s

2 (2) s

-

32(> 16) s

-

16

2 (8) s

16 (1) I

64

32 (2) s

16 (4) s

64

8 (8) s

16 (4) s

AG100

< 2

< 2 (> 4) s

< 2 (> 4) s

256

< 2 (> 128) s

< 2 (> 128) s

256

256 (1) I

256 (1) I

< 2

< 2

< 2

32

4 (8) s

32 (1) I

  1. MIC/2: concentration of plant extract added equal to 256 μg/ml for PA124, CM64, EA3, EA27, KP55, AG100; and to 512 μg/ml for EA289 and AG100ATET.
  2. MIC/5: concentration of plant extract added equal to 102.4 μg/ml for PA124, CM64, EA3, EA27, KP55, AG100; and to 204.8 μg/ml for EA289 and AG100ATET
  3. (): Values in bracket are folds increase of activity. S: synergy, I: indifference; (-): > 512 μg/ml
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BMC Complementary Medicine and Therapies

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