Table 8 Histological effects of the administration of ethanol extracts of D. rotundifolia on rats.
Dosage of administration | Histological effect on liver tissues | Histological effect on kidney tissues | Histological effect on Heart tissues | Histological effect on the testes |
|---|---|---|---|---|
0. 9 ml of normal saline | Tissues appeared normal. No evidence of tissue necrosis | Tissues appeared normal. No evidence of tissue necrosis | Tissues appeared normal. No evidence of tissue necrosis | Tissues appeared normal. No evidence of tissue necrosis |
250 mg/kg of D. rotundifolia | Densely stained nuclei, increased congestion of the vessels, all of which are evidence of tissue necrosis | Tissues appeared normal. No evidence of tissue necrosis | Tissues appeared normal. No evidence of tissue necrosis | Tissues appeared normal. No evidence of tissue necrosis |
500 mg/kg of D. rotundifolia | There was increased cytoplasmic eosinophilia and densely stained nuclei. There was also increased congestion of the vessels. These are evidence of liver cell damage. | Showed tubular necrosis and degenerative changes in the tubules | Tissues appeared normal. No evidence of tissue necrosis | Presence of ill defined testes with indistinct cell outlines. |