Skip to main content

Table 3 IC50, IC100 and SI of active extracts on the microfilariae of O. ochengi

From: Selective activity of extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi

Extract

Mammalian cells

Microfilariae

Acute toxicity in mice at 5 × IC50 on mfs

 

IC50 (μg/mL)

IC50 (μg/mL)

IC100 (μg/mL)

SI

 

MRH

93.75

45

62.5

2.08

Non-toxic

MLC

31.25

62.5

125

0.5

Not determined

HLH

250

95

125

2.63

Non-toxic

HLC

46.88

31.25

62.5

1.5

Not determined

  1. SI - Selectivity index. The codes of the extracts are: MRH = hexane extract of M. discoidea roots; MLC = methylene chloride extract of M. discoidea leaves; HLH = hexane extract of H. africanum leaves; HLC = methylene chloride extract H. africanum leaves.