Cytotoxicity screening of Bangladeshi medicinal plant extracts on pancreatic cancer cells

George, Sherine; Bhalerao, Siddharth V; Lidstone, Erich A; Ahmad, Irfan S; Abbasi, Atiya; Cunningham, Brian T; Watkin, Kenneth L

doi:10.1186/1472-6882-10-52

BMC Complementary Medicine and Therapies

Table 1 The names of the 56 plant extracts screened in this study.

From: Cytotoxicity screening of Bangladeshi medicinal plant extracts on pancreatic cancer cells

Extract No.	Plant	Family Name	Extract/partitionate	Fraction of Panc-1 cell survival
1	*Aglaia roxburghiana* Kurz	Meliaceae	n-Hexane partitionate of MeOH extract	0.02 ± 0.00
2	Alternanthera sessilis DC.	Amaranthaceae	Pet-ether fraction of MeOH extract	0.43 ± 0.14
3	Alternanthera sessilis DC.	Amaranthaceae	MeOH residue of MeOH extract	1.63 ± 0.41
4	*Alternanthera sessilis* DC.	Amaranthaceae	CHCl3 fraction of MeOH extract	0.04 ± 0.09
5	Amoora chittagonga Hiern	Meliaceae	Pet-ether partitionate of MeOH extract	0.36 ± 0.17
6	*Amoora chittagonga* Hiern	Meliaceae	CHCl3 partitionate of MeOH extract	0.02 ± 0.01
7	Amoora chittagonga Hiern	Meliaceae	EtOAc partitionate of MeOH extract	2.38 ± 0.35
9	Amoora rohituka (Roxb.) Wight & Arn.	Meliaceae	Pet-ether extract	0.10 ± 0.02
10	Amoora rohituka (Roxb.) Wight & Arn.	Meliaceae	MeOH extract	0.79 ± 0.18
11	Anisoptera glabra Kurz	Dipterocarpaceae	MeOH extract	3.18 ± 0.18
12	Anogeissus latifolia (Roxb.) Bedd	Combretaceae	EtOH extract	0.18 ± 0.06
13	Brunfelsia americana L.	Solanaceae	MeOH extract	0.79 ± 0.14
14	Brunfelsia latifolia Hort. ex. Steud.	Solanaceae	MeOH extract	1.46 ± 0.27
15	Buchanania lanzen Spreng.	Anacardiaceae	MeOH extract	0.23 ± 0.11
16	*Bursera serrata* Wall. ex. Coleb.	Burseraceae	Pet-ether extract	0.01 ± 0.01
17	*Bursera serrata* Wall. ex. Coleb.	Burseraceae	Dichloromethane extract	0.07 ± 0.03
18	Chukrasia tabularis Juss.	Meliaceae	MeOH extract	0.21 ± 0.11
19	Cinnamomum zeylanicum Blume	Lauraceae	MeOH extract	0.59 ± 0.15
20	*Citrus hystrix* DC.	Rutaceae	MeOH extract	0.02 ± 0.01
21	Combretum coccineum Engl. & Diels	Combretaceae	CHCl3 partitionate of acidified MeOH extract	0.35 ± 0.12
22	Combretum grandiflorum G.Don	Combretaceae	MeOH extract	1.15 ± 0.23
23	Eclipta prostrata L.	Asteraceae	MeOH extract	0.50 ± 0.03
24	Erioglossum edule Blume	Sapindaceae	MeOH extract	0.93 ± 0.03
25	Ficus indica L.	Moraceae	MeOH extract	0.57 ± 0.08
26	Garuga pinnata Roxb.	Burseraceae	MeOH extract	0.60 ± 0.19
27	Indigofera tinctoria L.	Papilionaceae	EtOH extract	0.77 ± 0.26
28	Lannea coromandelica (Houtt.) Merr.	Anacardiaceae	MeOH extract	2.44 ± 0.15
29	Nephelium litchi Sonn.	Sapindaceae	MeOH extract	0.27 ± 0.11
30	Nephelium longan (Lour.) Hook	Sapindaceae	MeOH extract	0.75 ± 0.19
31	Pesprum nocturnum L.	Solanaceae	MeOH extract	0.10 ± 0.02
32	Petunia meleagris Planch.	Solanaceae	MeOH extract	1.26 ± 0.29
33	Petunia phoenicea H.Jacq.	Solanaceae	MeOH extract	0.66 ± 0.22
34	*Petunia punctata* Paxton	Solanaceae	MeOH extract	0.08 ± 0.04
35	Petunia violaceae Lindl.	Solanaceae	MeOH extract	0.46 ± 0.16
37	*Phyllanthus reticulatus* Lodd.	Euphorbiaceae	CHCl3 fraction of pet-ether extract	0.03 ± 0.01
38	Phyllanthus reticulatus Lodd.	Euphorbiaceae	Hexane fraction of CH2Cl2 extract	0.60 ± 0.26
39	Phyllanthus reticulatus Lodd.	Euphorbiaceae	Acidified CHCl3 fraction of aqueous extract	1.25 ± 0.31
40	Phyllanthus reticulatus Lodd.	Euphorbiaceae	Acetone extract	1.36 ± 0.21
41	*Poivrea coccinea* DC.	Combretaceae	MeOH extract	0.04 ± 0.01
42	Pongamia glabra Vent.	Leguminosea	MeOH extract	0.14 ± 0.07
43	Protium serratum Engl.	Burseraceae	MeOH extract	1.65 ± 0.12
44	Pterospermum suberifolium Willd.	Sterculiaceae	MeOH extract	0.59 ± 0.06
45	Quisqualis indica L.	Combretaceae	Pet-ether extract	1.19 ± 0.31
46	Quisqualis indica L.	Combretaceae	MeOH extract	1.07 ± 0.24
47	Sapindus mukorossi Gaertn.	Sapindaceae	MeOH extract	1.57 ± 0.18
48	Semecarpus anacardium L.f.	Anacardiaceae	MeOH extract	2.10 ± 0.05
49	Shorea robusta C.F.Gaertn.	Dipterocarpaceae	EtOH extract	0.48 ± 0.16
52	Spondias mangifera Willd.	Anacardiaceae	MeOH extract	1.83 ± 0.14
53	Swintonia floribunda Griff.	Anacardiaceae	MeOH extract	2.92 ± 0.17
54	Terminalia bellerica Roxb.	Combretaceae	MeOH extract	0.22 ± 0.05
55	Terminalia bellerica Roxb.	Combretaceae	MeOH extract	1.64 ± 0.26
56	Trachyspermum ammi Sprague	Umbelliferae	EtOH extract	1.04 ± 0.18
57	Xanthoxylum budrunga DC.	Rutaceae	MeOH residue of MeOH extract	0.55 ± 0.05
59	Xylocurpus molucensis (Lamarck) M. Roemer	Meliaceae	n-Hexane partitionate of MeOH extract	1.12 ± 0.05
60	Xylocurpus molucensis (Lamarck) M. Roemer	Meliaceae	MeOH residue of MeOH extract	0.62 ± 0.18
61	Zizyphus jujuba Mill.	Rhamnaceae	MeOH extract	0.90 ± 0.19

The last column presents the anti-proliferative activity of each extract and the top nine cytotoxic extracts are in bold*.
*The PC biosensor was used to screen this library for extracts with anti-proliferative properties and the results are presented as the fraction of Panc-1 (human pancreatic cancer) cell survival relative to untreated controls after exposure to the plant extract. A testing concentration of 100 μg/mL and exposure time of 24 hours was used. Mean ± S.D. values of three replicates are reported here.

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