Figure 2
Protective effect of KRGCD on gastric mucosal lesions induced by indomethacin in mice. Stomachs from mice with vehicle (a) and pretreated with KRGCD at doses of 30 mg/kg (b), 100 mg/kg (c), and 300 mg/kg (d) at 1 hr before indomethacin administration. Quantitative analysis of KRGCD on the ulcer area (mm2) induced by indomethacin (e). n = 6 for each group. Each value represents the mean ± SEM. ** p < 0.01 vs. control mice, Dunnett's multiple-range test. Stomachs from mice with vehicle (f) and pretreated with KRGCD (100 mg/kg) (g), TCD (76 mg/kg) (h), and APD (96 mg/kg) (i) at 1 hr before indomethacin administration. Quantitative analysis of KRGCD, TCD, or APD on the ulcer area (mm2) induced by indomethacin (j). n = 8 for each group. Each value represents the mean ± SEM. * p < 0.05 vs. control mice, Student's t-test.