Table 1 Effect of β-sitosterol on development of ACF induced by DMH
ACF formation in rat colon | ||||
|---|---|---|---|---|
Groups | Total no. of ACF | No. of AC | Crypt multiplicity (AC/ACF) | % of ACF inhibition |
DMH | 52 ± 5.23a | 151 ± 12.31a | 2.9 ± 0.31a | - |
DMH + β-sitosterol (5 mg/Kg) | 47 ± 4.68a | 126 ± 10.36b | 2.6 ± 0.25b | 38.2 |
DMH + β-sitosterol (10 mg/Kg) | 38 ± 4.12b | 92 ± 10.21c | 2.4 ± 0.18c | 52.8 |
DMH + β-sitosterol (20 mg/Kg) | 29 ± 3.14c | 54 ± 8.94d | 1.8 ± 0.16d | 73.6 |