Skip to main content

Advertisement

Table 2 Effect of St. John's Wort on biochemical alterations on unstressed and immobilization stressed animals

From: Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice

Treatment (mg/kg) LPO (moles of MDA/mgpr) GSH (μmol of GSH/mgpr) Nitrite (μg/ml) Catalase (μmol of H2O2/min/mgpr)
Naïve 0.112 ± 0.002 0.091 ± 0.002 254.5 ± 2.62 0.807 ± 0.003
S JW (50) 0.102 ± 0.002NS 0.094 ± 0.003NS 250.1 ± 1.58NS 0.809 ± 0.002NS
S JW (100) 0.100 ± 0.003NS 0.096 ± 0.002NS 249.5 ± 2.62NS 0.810 ± 0.002NS
Control (RS) 0.623 ± 0.006a 0.011 ± 0.0007a 653.5 ± 2.66a 0.140 ± 0.001a
S JW (50)+RS 0.340 ± 0.009b 0.034 ± 0.001b 501 ± 2.3b 0.300 ± 0.003b
S JW (100)+RS 0.190 ± 0.006c 0.064 ± 0.002c 394.75 ± 1.8c 0.465 ± 0.006c
  1. Values are expressed as Mean ± SEM. aP < 0.05 as compared to naïve. bP < 0.05 as compared to control. cP < 0.05 as compared to St. John's Wort (50 mg/kg). (One-Way ANOVA followed by Tukey's test) NS = Not significant, RS = Restraint Stress, SJW = St. John's Wort, LPO = lipid peroxidation, MDA = malondialdehyde, GSH = reduced glutathione, mgpr = milligram protein