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Table 2 Effect of St. John's Wort on biochemical alterations on unstressed and immobilization stressed animals

From: Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice

Treatment (mg/kg)

LPO (moles of MDA/mgpr)

GSH (μmol of GSH/mgpr)

Nitrite

(μg/ml)

Catalase

(μmol of H2O2/min/mgpr)

Naïve

0.112 ± 0.002

0.091 ± 0.002

254.5 ± 2.62

0.807 ± 0.003

S JW (50)

0.102 ± 0.002NS

0.094 ± 0.003NS

250.1 ± 1.58NS

0.809 ± 0.002NS

S JW (100)

0.100 ± 0.003NS

0.096 ± 0.002NS

249.5 ± 2.62NS

0.810 ± 0.002NS

Control (RS)

0.623 ± 0.006a

0.011 ± 0.0007a

653.5 ± 2.66a

0.140 ± 0.001a

S JW (50)+RS

0.340 ± 0.009b

0.034 ± 0.001b

501 ± 2.3b

0.300 ± 0.003b

S JW (100)+RS

0.190 ± 0.006c

0.064 ± 0.002c

394.75 ± 1.8c

0.465 ± 0.006c

  1. Values are expressed as Mean ± SEM. aP < 0.05 as compared to naïve. bP < 0.05 as compared to control. cP < 0.05 as compared to St. John's Wort (50 mg/kg). (One-Way ANOVA followed by Tukey's test) NS = Not significant, RS = Restraint Stress, SJW = St. John's Wort, LPO = lipid peroxidation, MDA = malondialdehyde, GSH = reduced glutathione, mgpr = milligram protein