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Table 1 Effect of St. John's Wort on behavior alterations in unstressed and immobilization stressed animals

From: Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice

Treatment (mg/kg) Locomotor activity test Tail flick test Mirror chamber test
  (Counts/5 min) Tail flick latency (Sec) Latency to enter mirror chamber (sec) Average time spent per entry(sec)
Naïve 232 ± 1.32 1.75 ± 0.10 43.0 ± 1.08 48.75 ± 1.65
SJW(50) 239 ± 4.2 4.0 ± 1.5a 37.6 ± 3.4 46.32 ± 2.8
SJW (100) 243 ± 6.9a 5.0 ± 2.8a 34.6 ± 4.6 44.3 ± 1.6
Control (RS) 48.75 ± 1.65a 9.25 ± 0.19a 127 ± 1.95a 12.25 ± 0.85a
SJW(50)+ RS 105.25 ± 2.0b 8.15 ± 0.45a, NS 101 ± 2.3b 21.5 ± 0.83b
SJW (100)+RS 125.25 ± 1.8c 7.82 ± 0.29a, NS 78 ± 2.8c 33.75 ± 0.76c
  1. Valu0es are expressed as Mean ± SEM. aP < 0.05 as compared to naïve. bP < 0.05 as compared to control. cP < 0.05 as compared to St. John's Wort (50 mg/kg). (One-Way ANOVA followed by Tukey's test). NS = Not significant, RS = Restraint Stress, SJW = St. John's Wort