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Table 2 Frequency distribution of Chromosome Aberrations (CA) in 500 bone marrow cells examined (100 cells from each individuals).

From: Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study

   

Mitotic Index

Chromosome Aberration

Micronucleated Erythrocyte

Sperm Head Anomaly

Intervals (hr)

Drug potency

Series

% ± SE

% of Increased MI

% of Major CA

% of Other CA

Total CA ± SE

Prot.

% of MN in NCE

% of MN in PCE

P/N

% of Total MN in NCE & PCE

% of Prot,

% of SHA ± SE

% of prot.

6

30

T3

1.72 ± 0.18

 

3.2

6

9.2 ± 0.82

 

0.15

1.07

0.12

0.25 ± 0.04

 

1.62 ± 0.20

 
  

C3

1.84 ± 0.20

-0.12

3.8

7.4

11.2 ± 0.96

2.0

0.23

0.73

0.32

0.35 ± 0.02

0.10a

1.68 ± 0.25

0.06

 

200

T4

1.98 ± 0.23

 

3.4

5.2

8.6 ± 1.20

 

0.2

0.67

0.13

0.25 ± 0.04

 

1.48 ± 0.19

 
  

C4

1.6 ± 0.18

0.38

5

6.6

11.6 ± 1.44

3.0

0.23

0.51

0.30

0.29 ± 0.03

0.04a

1.56 ± 0.18

0.08

12

30

T3

1.84 ± 0.14

 

6

6.8

12.8 ± 0.82

 

0.2

0.58

0.25

0.27 ± 0.04

 

1.64 ± 0.18

 
  

C3

1,36 ± 0,17

0.48

7.6

9.8

17.4 ± 1.44

4.6a

0.43

0.64

0.45

0.49 ± 0.05

0.22a

2.12 ± 0.26

0.48

 

200

T4

2.08 ± 0.14

 

4.8

4.8

9.6 ± 1.03

 

0.17

0.41

0.23

0.21 ± 0.02

 

1.32 ± 0.16

 
  

C4

1.38 ± 0.19

0.7a

6.8

9.8

16.6 ± 1.60

7.0a

0.4

0.57

0.45

0.47 ± 0.06

0.26a

2.04 ± 0.23

0.72a

24

30

t3

1.7 ± 0.33

 

8.2

9.4

17.6 ± 1.52

 

0.54

1

0.31

0.65 ± 0.05

 

3.6 ± 0.24

 
  

C3

1.1 ± 0.21

0.6

15.2

14.6

29.8 ± 1.55

12.2c

0.81

1.44

0.28

0.95 ± 0.08

0.30a

4.98 ± 0.28

1.38b

 

200

T4

1.88 ± 0.35

 

6.6

6.6

13.2 ± 2.07

 

0.36

0.62

0.40

0.43 ± 0.04

 

3.1 ± 0.24

 
  

C4

0.98 ± 0.22

0.9

16.4

14.2

30.6 ± 1.56

17.4c

0.86

1.69

0.28

1.05 ± 0.07

0.62c

5.12 ± 0.28

2.02c

48

30

t3

2 ± 0.16

 

7.8

9

16.8 ± 0.77

 

0.54

0.76

0.45

0.61 ± 0.08

 

4.56 ± 0.39

 
  

C3

0.98 ± 0.14

1.02b

11

12.8

23.8 ± 1.34

7.0b

1.34

1.28

0.54

1.32 ± 0.08

0.71c

5.9 ± 0.41

1.34a

 

200

T4

2.34 ± 0.16

 

7

7.4

14.4 ± 0.90

 

0.32

0.41

0.50

0.35 ± 0.02

 

4.06 ± 0.39

 
  

C4

1.06 ± 0.13

1.28c

12

13.8

25.8 ± 0.96

11.4c

1.15

1.41

0.50

1.22 ± 0.04

0.87c

6.02 ± 0.38

1.96b

72

30

t3

2.76 ± 0.21

 

5.6

7.2

12.8 ± 1.38

 

0.47

0.64

0.33

0.51 ± 0.06

 

7.64 ± 0.16

 
  

C3

1.7 ± 0.18

1.06b

9.6

10.4

20 ± 1.45

7.2b

1.65

1.06

0.58

1.44 ± 0.09

0.93c

7.74 ± 0.30

0.10

 

200

T4

2.9 ± 0.22

 

6.6

4.4

11 ± 1.50

 

0.26

0.59

0.30

0.33 ± 0.05

 

4.86 ± 0.33

 
  

C4

1.56 ± 0.07

1.34c

9.4

11.2

20.6 ± 1.64

9.6c

1.17

1.62

0.60

1.32 ± 0.08

0.99c

7.28 ± 0.20

2.42c

96

30

t3

2.3 ± 0.23

 

4.6

7.6

12.2 ± 1.14

 

0.28

0.92

0.17

0.37 ± 0.06

 

2.72 ± 0.18

 
  

C3

1.26 ± 0.15

1.04c

8.2

10.2

18.4 ± 1.60

6.2a

0.86

0.94

0.49

0.91 ± 0.09

0.54c

4.64 ± 0.34

1.92b

 

200

T4

2.56 ± 0.26

 

3.2

5.6

9.8 ± 1.24

 

0.18

0.71

0.16

0.25 ± 0.02

 

2.38 ± 0.24

 
  

C4

1.42 ± 0.10

1.14b

7.4

10.4

17.6 ± 1.60

7.8b

0.94

1.01

0.49

0.97 ± 0.09

0.72c

5.14 ± 0.19

2.76c

  1. a = p < 0.05, b = p < 0.01, c = p < 0.001 (significance levels of t-test) Mitotic Indices (MI) in 5000 cells (1000 cells from each individuals), Micronuclei in normochromatic erythrocytes (NCE) and polychromatic erythrocytes (PCE) in 5000 cells (1000 cells from each individuals) and Sperm head-shape abnormality (SHA) in 5000 sperm (1000 sperm from each individuals) at different fixation intervals in CdCl2 treated mice post-fed with Cad Sulph-30 (T3) and Cad Sulph-200 (T4) separately and respective alcohol-30 (C3) and alcohol-200 (C4) fed controls.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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