Figure 3From: Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC Fasting blood glucose values and effects of curcumin on DN measured by urinary albumin/creatinine in noDM and DM mice. (a) Fasting blood glucose in mice in Experiments 1 and 2. 24 h urine was collected to measure Ualb/cr in noDM and DM mice. (b) Ualb/cr from urine collected on days 9-15 for noDM and DM mice given control chow (0 ppm curcumin) or chow with 5,000 ppm curcumin. Mice were fed curcumin post-Stz injections (Experiment 1). (c) Ualb/cr at 2, 4 and 7 weeks for noDM and DM mice given control chow (0 ppm) or curcumin chow (data pooled for mice fed 5,000 and 7,500 ppm curcumin). Mice were fed curcumin pre-Stz injections (Experiment 2). All data are log-transformed (log10). *P < 0.05Back to article page