Fig. 3

Infarct volumes and regions of edema. A Representative images of 1-mm brain coronal slices stained with TTC, displaying the total infarct volumes (lower column) and infarct areas 24 h after middle cerebral artery occlusion (MCAO). B Numerical evaluation of the entire edematous region. The results are shown as means ± SDs (n = 5). S, a single dose of CRex at 1,000 or 3,000 mg/kg p.o.; T, two doses of CRex at 300, 1,000, or 3,000 mg/kg p.o.; ^### p < 0.001 vs. sham-operated group; ***p < 0.001 vs. MCAO control group