Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Research article

    The herbal formula KH-204 is protective against erectile dysfunction by minimizing oxidative stress and improving lipid profiles in a rat model of erectile dysfunction induced by hypercholesterolaemia

    Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidativ...

    Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang and Sae Woong Kim

    BMC Complementary and Alternative Medicine 2017 17:129

    Published on: 24 February 2017

  2. Research article

    The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function

    Lianhuaqingwen Capsule (LH-C) is a traditional Chinese medicine (TCM) formula used to treat respiratory tract infectious diseases in Chinese. The aim of this study was to determine the antiviral activity of LH...

    Yuewen Ding, Lijuan Zeng, Runfeng Li, Qiaoyan Chen, Beixian Zhou, Qiaolian Chen, Pui leng Cheng, Wang Yutao, Jingping Zheng, Zifeng Yang and Fengxue Zhang

    BMC Complementary and Alternative Medicine 2017 17:130

    Published on: 24 February 2017

  3. Research article

    Allium hookeri root extract exerts anti-inflammatory effects by nuclear factor-κB down-regulation in lipopolysaccharide-induced RAW264.7 cells

    Allium hookeri (AH) is widely consumed as a vegetable and herbal medicine in southeastern Asia. AH has been reported antioxidant, antimicrobial, improvement of bone health and antidiab...

    Ja-Young Jang, Min-Jung Lee, Bo-Ram You, Jong-Sik Jin, Sung-Hyen Lee, Ye-Rang Yun and Hyun Ju Kim

    BMC Complementary and Alternative Medicine 2017 17:126

    Published on: 23 February 2017

  4. Research article

    Chemical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis

    Many plants of boreal forest of Quebec have been used by Native Americans to treat a variety of microbial infections. However, the antiviral activities of these plants have been seldom evaluated on cellular mo...

    Serge Lavoie, Isabelle Côté, André Pichette, Charles Gauthier, Michaël Ouellet, Francine Nagau-Lavoie, Vakhtang Mshvildadze and Jean Legault

    BMC Complementary and Alternative Medicine 2017 17:123

    Published on: 22 February 2017

  5. Research article

    Anti-obesity effect of ethanolic extract from Cosmos caudatus Kunth leaf in lean rats fed a high fat diet

    Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiven...

    Hafeedza Abdul Rahman, Najla Gooda Sahib, Nazamid Saari, Faridah Abas, Amin Ismail, Muhammad Waseem Mumtaz and Azizah Abdul Hamid

    BMC Complementary and Alternative Medicine 2017 17:122

    Published on: 22 February 2017

  6. Research article

    Exploration of anti-cancer effects and mechanisms of Zuo-Jin-Wan and its alkaloid components in vitro and in orthotopic HepG2 xenograft immunocompetent mice

    Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment of cancers. However, the efficacies and mec...

    Shun-Ting Chou, Chien-Yun Hsiang, Hsin-Yi Lo, Hui-Fen Huang, Ming-Tsung Lai, Ching-Liang Hsieh, Su-Yin Chiang and Tin-Yun Ho

    BMC Complementary and Alternative Medicine 2017 17:121

    Published on: 20 February 2017

  7. Research article

    Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury

    This study explored Bacopa monnieri, a medicinal Ayurvedic herb, as a cardioprotectant against ischemia/reperfusion injury using cardiac function and coronary flow as end-points.

    Sirintorn Srimachai, Sylvie Devaux, Celine Demougeot, Sarawut Kumphune, Nina D. Ullrich, Ernst Niggli, Kornkanok Ingkaninan, Natakorn Kamkaew, C. Norman Scholfield, Sompol Tapechum and Krongkarn Chootip

    BMC Complementary and Alternative Medicine 2017 17:117

    Published on: 20 February 2017

  8. Research article

    Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells

    Activation of macrophage is involved in many inflammation diseases. Lipopolysaccharide (LPS) is a powerful inflammatory signal contributing to monocytes/macrophages activation associated with increased proinfl...

    Haijian Sun, Weiwei Cai, Xu Wang, Yanling Liu, Bao Hou, Xuexue Zhu and Liying Qiu

    BMC Complementary and Alternative Medicine 2017 17:120

    Published on: 20 February 2017

  9. Research article

    UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss

    The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too exp...

    Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim and Qi Jia

    BMC Complementary and Alternative Medicine 2017 17:114

    Published on: 16 February 2017

  10. Research article

    Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria

    The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been...

    Jongsung Lee, Youn Hwa Nho, Seok Kyun Yun and Young Sun Hwang

    BMC Complementary and Alternative Medicine 2017 17:113

    Published on: 16 February 2017

  11. Research article

    Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids

    Development of new and effective therapeutics for sexually transmitted herpes simplex virus-2 (HSV-2) infection is important from public health perspective. With an aim to identify natural products from medici...

    Ajay Kesharwani, Suja Kizhiyedath Polachira, Reshmi Nair, Aakanksha Agarwal, Nripendra Nath Mishra and Satish Kumar Gupta

    BMC Complementary and Alternative Medicine 2017 17:110

    Published on: 14 February 2017

  12. Research article

    Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo

    Arsenic trioxide (ATO) is approved for treating terminal-stage liver cancer in China. Cryptotanshinone (CT), a STAT3 inhibitor, has exhibited certain anti-tumor potency; however, the use of CT enhanced ATO for...

    Li Shen, Guangshun Zhang, Zhaohuan Lou, Guanhua Xu and Guangji Zhang

    BMC Complementary and Alternative Medicine 2017 17:106

    Published on: 10 February 2017

  13. Research article

    Promotion of HepG2 cell apoptosis by flower of Allium atroviolaceum and the mechanism of action

    Liver cancer is a high incidence and fatal disease, the fifth most frequent cancer worldwide that is usually diagnosed at an advanced stage. The number of deaths from liver cancer has not declined even followi...

    S. Khazaei, R. Abdul Hamid, N. Mohd Esa, V. Ramachandran, Ghomi Tabatabaee F. Aalam, A. Etemad and P. Ismail

    BMC Complementary and Alternative Medicine 2017 17:104

    Published on: 10 February 2017

  14. Research article

    Study of phytochemical, anti-microbial, anti-oxidant, and anti-cancer properties of Allium wallichii

    There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have invest...

    Jaya Bhandari, BushraTaj Muhammad, Pratiksha Thapa and Bhupal Govinda Shrestha

    BMC Complementary and Alternative Medicine 2017 17:102

    Published on: 8 February 2017

  15. Research article

    Antibacterial and antioxidant properties of crude extract, fractions and compounds from the stem bark of Polyscias fulva Hiern (Araliaceae)

    In our previous work, the dichloromethane-methanol (1:1 v/v) extract, fractions and isolated compounds from Polyscias fulva stem bark showed interesting antifungal activity. As a continuity of that work, this stu...

    Guy Sedar Singor Njateng, Zhizhi Du, Donatien Gatsing, Raymond Simplice Mouokeu, Yaping Liu, Hong-Xia Zang, Jianlong Gu, Xiaodong Luo and Jules-Roger Kuiate

    BMC Complementary and Alternative Medicine 2017 17:99

    Published on: 7 February 2017

  16. Research article

    Anti-influenza virus activity of extracts from the stems of Jatropha multifida Linn. collected in Myanmar

    To contribute to the development of novel anti-influenza drugs, we investigated the anti-influenza activity of crude extracts from 118 medicinal plants collected in Myanmar. We discovered that extract from the...

    Masaki Shoji, So-Yeun Woo, Aki Masuda, Nwet Nwet Win, Hla Ngwe, Etsuhisa Takahashi, Hiroshi Kido, Hiroyuki Morita, Takuya Ito and Takashi Kuzuhara

    BMC Complementary and Alternative Medicine 2017 17:96

    Published on: 7 February 2017

  17. Research article

    Spasmogenic and spasmolytic activity of rind of Punica granatum Linn

    Rind of Punica granatum is traditionally used in treatment of abdominal cramps and various GIT disorders. So far spasmolytic activity of rind of Punica granatum has been reported using in vitro model. However, it...

    Niaz Ali, Ayesha Jamil, Syed Wadood Ali Shah, Ismail Shah and Ghayour Ahmed

    BMC Complementary and Alternative Medicine 2017 17:97

    Published on: 7 February 2017

  18. Research article

    Effects of Angelicae dahuricae Radix on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in mice model

    Atopic dermatitis (AD) is an inflammatory, chronically relapsing, and intensively pruritic skin disease that affect 10–30% of the global population. Angelicae dahuricae Radix (ADR) has been reported to be anti-in...

    Jin Mo Ku, Se Hyang Hong, Hyo In Kim, Hye Sook Seo, Yong Cheol Shin and Seong-Gyu Ko

    BMC Complementary and Alternative Medicine 2017 17:98

    Published on: 7 February 2017

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