Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Research article

    Acetone leaf extracts of some South African trees with high activity against Escherichia coli also have good antimycobacterial activity and selectivity index

    Tuberculosis is a world-wide problem affecting humans and animals. There is increasing development of resistance of the pathogens to current antimycobacterial agents. Many authors have investigated activities ...

    Ishaku L. Elisha, Francien S. Botha, Balungile Madikizela, Lyndy J. McGaw and Jacobus N. Eloff

    BMC Complementary and Alternative Medicine 2017 17:327

    Published on: 19 June 2017

  2. Research article

    XuefuZhuyu decoction protected cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy

    XuefuZhuyu decoction (XFZY) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as unstable angina pectoris and myocardial ischemia-reperfusion injury...

    Xiaowen Shi, Haiyan Zhu, Yuanyuan Zhang, Mingmei Zhou, Danli Tang and Huamin Zhang

    BMC Complementary and Alternative Medicine 2017 17:325

    Published on: 19 June 2017

  3. Research article

    Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

    Diabetes mellitus (DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles, currently the extracts from leaves of cynara scolymus has been discovered to treat metabolic disorders ...

    Maryem Ben Salem, Rihab Ben Abdallah Kolsi, Raouia Dhouibi, Kamilia Ksouda, Slim Charfi, Mahdi Yaich, Serria Hammami, Zouheir Sahnoun, Khaled Mounir Zeghal, Kamel Jamoussi and Hanen Affes

    BMC Complementary and Alternative Medicine 2017 17:328

    Published on: 19 June 2017

  4. Research article

    Involvement of the glutamate/glutamine cycle and glutamate transporter GLT-1 in antidepressant-like effects of Xiao Yao san on chronically stressed mice

    Xiao Yao San (XYS) is an herbal prescription which is used in the treatment of depression for thousands of years from Song dynasty in China (960–1127 A...

    Xiu-Fang Ding, Yue-Hua Li, Jia-Xu Chen, Long-Ji Sun, Hai-Yan Jiao, Xin-Xin Wang and Yan Zhou

    BMC Complementary and Alternative Medicine 2017 17:326

    Published on: 19 June 2017

  5. Research article

    Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model

    The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylv...

    Yan Jiang, Yan Lin, Yi-Juan Hu, Xiao-Jun Song, Hong-Hua Pan and Hong-Jian Zhang

    BMC Complementary and Alternative Medicine 2017 17:320

    Published on: 17 June 2017

  6. Research article

    Effects of Karela (Bitter Melon; Momordica charantia) on genes of lipids and carbohydrates metabolism in experimental hypercholesterolemia: biochemical, molecular and histopathological study

    Hypercholesterolemia is a serious diseases associated with type-2 diabetes, atherosclerosis, cardiovascular disorders and liver diseases. Humans seek for safe herbal medication such as karela (Momordica charan...

    Dalia Yossri Saad, Mohamed Mohamed Soliman, Ahmed A. Baiomy, Magdy Hassan Yassin and Hanan Basiouni El-Sawy

    BMC Complementary and Alternative Medicine 2017 17:319

    Published on: 17 June 2017

  7. Research article

    The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms

    Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to...

    Ramani Karunakaran, M. Ira Thabrew, G. Mayuri Thammitiyagodage, B. Prasanna Galhena and L.D.A. Menuka Arawwawala

    BMC Complementary and Alternative Medicine 2017 17:312

    Published on: 14 June 2017

  8. Research article

    The effect of Astragalus polysaccharides on attenuation of diabetic cardiomyopathy through inhibiting the extrinsic and intrinsic apoptotic pathways in high glucose -stimulated H9C2 cells

    Apoptosis plays a critical role in the progression of diabetic cardiomyopathy (DC). Astragalus polysaccharides (APS), an extract of astragalus membranaceus (AM), is an effective cardioprotectant. Currently, littl...

    Shuqin Sun, Shuo Yang, Min Dai, Xiujuan Jia, Qiyan Wang, Zheng Zhang and Yongjun Mao

    BMC Complementary and Alternative Medicine 2017 17:310

    Published on: 13 June 2017

  9. Research article

    Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract

    Since long, natural sources have been explored for possible managements of various diseases. In this context, the study is designed to evaluate Isodon rugosus Wall. ex Benth for biological potentials including an...

    Anwar Zeb, Farhat Ullah, Muhammad Ayaz, Sajjad Ahmad and Abdul Sadiq

    BMC Complementary and Alternative Medicine 2017 17:284

    Published on: 30 May 2017

  10. Research article

    Investigation of antioxidant, antimicrobial and toxicity activities of lichens from high altitude regions of Nepal

    Several lichen species are reported to be used tradiationally in many theraupatic practices. Many lichen species are reported as sources of several bioactive natural compounds. Several lichen species of Nepal ...

    Baidya Nath Jha, Mitesh Shrestha, Durga Prasad Pandey, Tribikram Bhattarai, Hari Datta Bhattarai and Babita Paudel

    BMC Complementary and Alternative Medicine 2017 17:282

    Published on: 25 May 2017

  11. Research article

    Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells

    Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system.

    Victor Kuete, Fabrice W. Fokou, Oğuzhan Karaosmanoğlu, Veronique P. Beng and Hülya Sivas

    BMC Complementary and Alternative Medicine 2017 17:280

    Published on: 25 May 2017

  12. Research article

    Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

    Recinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the e...

    Aimé Gabriel Fankam, Jules-Roger Kuiate and Victor Kuete

    BMC Complementary and Alternative Medicine 2017 17:168

    Published on: 24 March 2017

  13. Research article

    Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells

    Sophorae Flos (SF) is a composite of flowers and buds of Styphnolobium japonicum (L.) Schott and has been used in traditional Korean and Chinese medicine for the treatment of hemostasis and inflammation. Previous...

    Jeong-Mi Kim, Jung-Han Lee, Guem-San Lee, Eun-mi Noh, Hyun-Kyung Song, Dong Ryun Gu, Seong-Cheol Kim, Seoung Hoon Lee, Kang-Beom Kwon and Young-Rae Lee

    BMC Complementary and Alternative Medicine 2017 17:164

    Published on: 23 March 2017

    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2017 17:235

  14. Research article

    Characterization and mechanisms of anti-influenza virus metabolites isolated from the Vietnamese medicinal plant Polygonum chinense

    Polygonum chinense Linn. is a common medicinal plant in Southeast Asia and has been used in traditional medicine in Vietnam. The plant contains phytochemicals with various biological p...

    Thu Thi Tran, Meehyein Kim, Yejin Jang, Hye Won Lee, Hoa Thi Nguyen, Thanh Ngoc Nguyen, Hae Woong Park, Quang Le Dang and Jin-Cheol Kim

    BMC Complementary and Alternative Medicine 2017 17:162

    Published on: 21 March 2017

  15. Research article

    Evaluation of the antimycobacterial activity of crude extracts and solvent fractions of selected Ethiopian medicinal plants

    Tuberculosis (TB) is a global health problem complicated by drug resistance and human immunodeficiency virus that has dramatically increased active TB. Several medicinal plants are used traditionally to treat ...

    Wubayehu Kahaliw, Abraham Aseffa, Markos Abebe, Mekonen Teferi and Ephrem Engidawork

    BMC Complementary and Alternative Medicine 2017 17:143

    Published on: 8 March 2017

  16. Research article

    Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats

    In acupuncture practice, the most important step is to confirm the location of a sensitized acupoint which reflects a diagnosis and can be stimulated with a specialized needle to treat the disease. Abnormal sy...

    Wei He, Xiao-Yu Wang, Hong Shi, Wan-Zhu Bai, Bin Cheng, Yang-Shuai Su, Xiao-Chun Yu, Xiang-Hong Jing and Bing Zhu

    BMC Complementary and Alternative Medicine 2017 17:141

    Published on: 7 March 2017

  17. Research article

    Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome

    Modified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in the clinical setting. Our study focuses on the comp...

    Limei Yao, Jingjing Wei, Si Shi, Kunbin Guo, Xiangyu Wang, Qi Wang, Dingsheng Chen and Weirong Li

    BMC Complementary and Alternative Medicine 2017 17:132

    Published on: 28 February 2017

  18. Research article

    The herbal formula KH-204 is protective against erectile dysfunction by minimizing oxidative stress and improving lipid profiles in a rat model of erectile dysfunction induced by hypercholesterolaemia

    Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidativ...

    Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang and Sae Woong Kim

    BMC Complementary and Alternative Medicine 2017 17:129

    Published on: 24 February 2017

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