Clinical research

Edited by Jianping Liu

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Research article

    Rhythm-centred music making in community living elderly: a randomized pilot study

    Quality of life has become an important aspect in the measurement of the health of an individual as the population ages. Rhythm-centred music making (RMM) has been shown to improve physical, psychological and ...

    Angela Frances Yap, Yu Heng Kwan, Chuen Seng Tan, Syed Ibrahim and Seng Bin Ang

    BMC Complementary and Alternative Medicine 2017 17:311

    Published on: 14 June 2017

  2. Research article

    Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome: a multi-center, double-blind, randomized, placebo-controlled trial

    Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulga...

    Nuo Li, Wenbin Zhao, Jianmin Xing, Jianping Liu, Guangzhong Zhang, Yunbi Zhang, Yuanwen Li, Wali Liu, Fei Shi and Yanping Bai

    BMC Complementary and Alternative Medicine 2017 17:264

    Published on: 15 May 2017

  3. Research article

    Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial

    Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. T...

    Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani and Roman Huber

    BMC Complementary and Alternative Medicine 2017 17:172

    Published on: 28 March 2017

  4. Research article

    Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review

    Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific b...

    Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María C. Pérez-Yus, Marcelo M. P. Demarzo, Jesús Montero-Marín, Mauro García-Toro and Javier García-Campayo

    BMC Complementary and Alternative Medicine 2017 17:125

    Published on: 23 February 2017

  5. Research article

    Feasibility study of transfer function model on electrocardiogram change caused by acupuncture

    Acupuncture treatments that regulate the heart are used to treat various clinical disorders and conditions. Although many studies have been conducted to measure quantitatively the effects of acupuncture, thus ...

    Haebeom Lee, Hyunho Kim, Jungkuk Kim, Hwan-Sup Oh, Young-Jae Park and Young-Bae Park

    BMC Complementary and Alternative Medicine 2017 17:101

    Published on: 8 February 2017

  6. Research article

    A Randomized controlled trial of the effect of yoga and peer support on glycaemic outcomes in women with type 2 diabetes mellitus: a feasibility study

    Type two diabetes is a complex and demanding chronic disease and its impact in a state (Kerala) which leads India in terms of the number of people with Diabetes is profound. Though the male to female ratio amo...

    Aswathy Sreedevi, Unnikrishnan Ambika Gopalakrishnan, Sundaram Karimassery Ramaiyer and Leelamoni Kamalamma

    BMC Complementary and Alternative Medicine 2017 17:100

    Published on: 7 February 2017

  7. Research article

    Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypertension and hyperhomocysteinemia - a randomized, double-blind, placebo-controlled, cross-over trial

    Nutrition plays an important role in prevention and management of cardiovascular diseases (CVD) in early stages. Recent research demonstrated beneficial effects of various nutritional ingredients on vascular h...

    Claudia A. Reule, Birgit Goyvaerts and Christiane Schoen

    BMC Complementary and Alternative Medicine 2017 17:92

    Published on: 2 February 2017

  8. Research article

    A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial

    Many previous studies of electroacupuncture used combined therapy of electroacupuncture and systemic manual acupuncture, so it was uncertain which treatment was effective. This study evaluated and compared the...

    Bong Hyun Kim, Kyuseok Kim and Hae Jeong Nam

    BMC Complementary and Alternative Medicine 2017 17:85

    Published on: 31 January 2017

  9. Research article

    Comparison of the placebo effect between different non-penetrating acupuncture devices and real acupuncture in healthy subjects: a randomized clinical trial

    Several studies have used placebo acupuncture methods in recent years as a way for blinding therapeutic effect of acupuncture, however placebo method selection has not followed enough methodological criteria t...

    Leonardo Yung dos Santos Maciel, Paula Michele dos Santos Leite, Mauricio Lima Poderoso Neto, Andreza Carvalho Rabelo Mendonça, Carla Carolina Alves de Araujo, Jersica da Hora Santos Souza and Josimari Melo DeSantana

    BMC Complementary and Alternative Medicine 2016 16:518

    Published on: 15 December 2016

  10. Research article

    Impact of ao-dake-humi, Japanese traditional bamboo foot stimulator, on lower urinary tract symptoms, constipation and hypersensitivity to cold: a single-arm prospective pilot study

    Ao-dake-humi is a traditional Japanese bamboo foot stimulator consisting of a half-pipe-shaped step made of bamboo used to stimulate the foot by stepping on it, and is commonly used to...

    Tomonori Minagawa, Tetsuichi Saitou, Toshiro Suzuki, Takahisa Domen, Hitoshi Yokoyama, Masakuni Ishikawa, Shiro Hirakata, Takashi Nagai, Masaki Nakazawa, Teruyuki Ogawa and Osamu Ishizuka

    BMC Complementary and Alternative Medicine 2016 16:513

    Published on: 9 December 2016

  11. Research article

    The quality of reporting of randomized controlled trials of electroacupuncture for stroke

    Electroacupuncture (EA), as an extension technique of acupuncture based on traditional acupuncture combined with modern electrotherapy, is commonly used for stroke in clinical treatment and researches. However...

    Jing-jing Wei, Wen-ting Yang, Su-bing Yin, Chen Wang, Yan Wang and Guo-qing Zheng

    BMC Complementary and Alternative Medicine 2016 16:512

    Published on: 9 December 2016

  12. Study protocol

    Protocol of a prospective study for the combination treatment of Shu-Gan-jian-Pi decoction and steroid standard therapy in autoimmune hepatitis patients

    Prednisone plus azathioprine is considered the mainstay of therapy in the current recommendations for autoimmune hepatitis (AIH). However, it does not provide good benefits for AIH patients because of its seri...

    Xiao-ling Chi, Huan-ming Xiao, Yu-bao Xie, Gao-shu Cai, Jun-min Jiang, Guang-jun Tian, Mei-jie Shi, Shu-duo Wu, Peng-tao Zhao and Hui-jun Chen

    BMC Complementary and Alternative Medicine 2016 16:505

    Published on: 7 December 2016

  13. Research article

    Evaluation of Salvadora persica L. and green tea anti-plaque effect: a randomized controlled crossover clinical trial

    In the author’s earlier in vitro investigation, a combination of 0.25 mg/ml green tea and 7.82 mg/ml Salvadora persica L. aqueous extracts was found to exhibit significant synergistic anti-bacterial and anti-adhe...

    Hayder Raad Abdulbaqi, Wan Harun Himratul-Aznita and Nor Adinar Baharuddin

    BMC Complementary and Alternative Medicine 2016 16:493

    Published on: 1 December 2016

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