Could the Sasang constitution itself be a risk factor of abdominal obesity?
© Jang et al.; licensee BioMed Central Ltd. 2013
Received: 11 July 2012
Accepted: 8 February 2013
Published: 2 April 2013
Abdominal obesity (AO) is a medical condition in which excess body fat accumulates in the abdomen. It may cause adverse effects on health and result in reduced life expectancy or increased health problems. While various genetic approaches have explained the risks of AO in Western society, the Sasang constitution (SC) has been identified as a risk factor in Korean medicine. Different SC types are associated with different fat distribution, body shapes and susceptibility to diseases. We evaluated whether the SC type could be a risk for AO in a cross-sectional study among Koreans.
In total, 2,528 subjects aged over 30 years were recruited from 23 medical clinics. We collected waist circumference (WC), weight, height, and some clinical information for AO from the subjects. A Chi-square test and a one-way ANOVA were performed according to SC type (p < .05), while multiple logistic regression was used to produce odds ratios (ORs).
The rates of AO in Tae-eumin (TE), Soeumin (SE), and Soyangin (SY) types were 63.7%, 14.7%, and 32.8% in males and 84.8%, 41.7%, and 52.8% in females, respectively. The TE type was associated with increased AO prevalence compared with the SE and SY types in males (OR 1.79; 95% CI 1.02–3.15, p = 0.044 and OR 1.74; 95% CI 1.18–2.58, p = 0.006, respectively) and females (OR 1.51; 95% CI 1.03–2.23, p = 0.037 and OR 1.88; 95% CI 1.32–2.68, p < 0.001, respectively) after adjusting for age, BMI, hypertension, diabetes mellitus, hypertriglyceridemia, and low HDL cholesterol.
This study suggested that SC, particularly the TE type, might be significantly and independently associated with AO and could be considered a risk factor in predicting AO.
KeywordsAbdominal obesity Sasang constitutional medicine Prevalence Waist circumference Risk factor
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems . Obesity, especially abdominal obesity (AO), is a substantial risk factor for hypertension, metabolic disease, cardiovascular disease, gallbladder disease, osteoarthritis, and sleep apnea .
Furthermore, the waist circumference (WC) plays pivotal roles in those diseases because of its central fat distribution [3–7]. Therefore, the World Health Organization (WHO) has classified obese guide according to not only body mass index (BMI) but also WC  and the National Cholesterol Education Program Adult Treatment Panel III also has defined AO as one of important factors for metabolic syndrome . Eventually, the WHO has identified that human beings should overcome AO in the 21st century and observed that the wait for a cure may take a long time . The fundamental cause of AO is presumed to be a combination of environmental factors (inappropriate eating and physical inactivity) and the organism’s genes, such as the 5-HT2A gene and glucocorticoid receptor (GR) gene in Western society [11–15].
Sasang constitutional medicine (SCM) is a tailored Korean traditional medicine that classifies human beings into four constitutions: Taeyangin (TY), Soyangin (SY), Tae-eumin, (TE), and Soeumin (SE) . Each constitution is classified by characteristics of body shape, face, voice, and psychological and physiological aspects [17, 18], and those characteristics are different from one constitution to another . Therefore, each constitution has a different susceptibility to pathology and several chronic diseases. Hypertension and diabetes mellitus (DM) were revealed to be associated with a specific Sasang constitution (SC) [19–23].
According to SCM theory, lung hypo-function and liver hyper-function are related to a large WC, and the TE type is associated with hyperactive liver function and a developed waist area [16, 17]. We hypothesize that SC could be a risk for AO. Several family studies have been conducted to investigate the genetic evidence for SC, and they found that SC could be not only inherent but also a risk factor for obesity [24, 25]. However, there has been no clinical study to show that SC could a risk factor for AO.
In this study, we present indirect evidence of whether SC could be a risk factor for AO among Koreans.
This was a cross-sectional study conducted from Nov. 2007 to Jul. 2011 in 23 Korean medical clinics (KMCs).
Study subjects and size
This study was approved by the Korea Institute of Oriental Medicine (KIOM) Institutional Review Board (I-0910/02-001). Written informed consent for participation in this study was obtained from each of the subjects.
Sasang constitutional diagnosis
An SCM expert at each hospital diagnosed individual SC types. For accurate diagnoses, we strictly adhered to defined qualifications of the experts and subject criteria. The SCM experts had more than 5 years of experience in clinical practice. The administration of constitution-specific pharmaceuticals was used as an additional method to confirm the subject SC. A more detailed procedure of diagnosing SC was described in Song’s study .
We collected WC measurements to determine the AO prevalence according to SC. We also collected data on age, sex, body mass index (BMI), and blood pressure and blood samples to control for the influence of confounding factors, which are important risk factors for AO [28, 29]. WC was measured around the level of the umbilical scar of the subjects, who took their upper clothing off and stood in an erect posture with their arms folded in front of their chest . BMI was indirectly calculated through the weight and height, and the blood pressure was measured from each subject’s left upper arm after enough rest. To reduce measurement bias among the KMCs, all instructors were educated by KIOM at least once per year, and KIOM monitored the progress of the data collection. All instructors followed a standard operation procedure (SOP) that was developed for the “Korea Constitution Multicenter Study” [26, 30].
Blood samples were collected after more than 12 hours of fasting, and the fasting blood glucose, triglyceride (TG) and HDL cholesterol levels were tested by an authorized institution.
Hypertension was diagnosed by following the guidelines of the 7th Report of the JNC as ≥ 90 mmHg for diastolic pressure, ≥140 mmHg for systolic pressure or taking medicine for the treatment of high blood pressure . DM was diagnosed with the ADA criteria as ≥126 mg/dl of fasting plasma glucose or taking medicine for the treatment of DM . Hypertriglyceridemia was diagnosed as TG ≥150 mg/dl, and low HDL cholesterol was diagnosed as HDL cholesterol <40 mg/dl in males and <50 mg/dl in females. To diagnose AO, we followed the WHO Report of Asia-Pacific guideline of WC ≥ 90 cm for males and ≥ 80 cm for females .
Considering the influence of sexual differences, all analyses were separately conducted in males and females. A one-way ANOVA was used to compare continuous variables (Scheffé’s post-hoc analysis). A Chi-square test was performed to compare the prevalence of AO according to SC. Multiple logistic regression was used to calculate odds ratios (ORs) for AO. To evaluate whether the SC could be a risk factor for AO, covariant variables, including age, BMI, hypertension, DM, hypertriglyceridemia, and low HDL cholesterol, were considered. We conducted all of the analyses using SPSS 17.0 software (SPSS Inc., Chicago, IL). The statistical levels of significance were considered to be p values <0.05.
The Characteristics of subjects according to gender and constitution
52.5 ± 12.1b
48.5 ± 12.2a,b
52.8 ± 12.4a
25.8 ± 2.8b,c
21.9 ± 2.5a,b
23.7 ± 2.6a,c
Systolic blood pressure (mmHg)
127.2 ± 14.5b,c
120.4 ± 14.6b
122.8 ± 14.5c
Diastolic blood pressure (mmHg)
81.7 ± 10.5b
77.4 ± 11.3a,b
79.7 ± 10.1c
Fasting blood glucose (mg/dl)
105.6 ± 31.2
100.8 ± 33.7
105.8 ± 33.6
170.0 ± 106.4b
126.0 ± 67.1a,b
158.3 ± 106.0c
HDL cholesterol (mg/dl)
39.1 ± 9.6b,c
43.2 ± 9.9b
41.8 ± 11.1c
92.4 ± 7.4
82.2 ± 7.1
86.5 ± 7.9
53.6 ± 12.7b,c
49.3 ± 12.9b
50.19 ± 12.1c
25.5 ± 3.0b,c
21.5 ± 2.5a,b
22.8 ± 2.6a,c
Systolic blood pressure (mmHg)
122.6 ± 17.2b,c
116.2 ± 16.0b
117.3 ± 14.6c
Diastolic blood pressure (mmHg)
78.3 ± 11.7b,c
74.2 ± 11.3b
75.2 ± 10.5c
Fasting blood glucose (mg/dl)
101.7 ± 315b
92.9 ± 15.6a,b
98.0 ± 32.1c
137.2 ± 89.4b,c
100.8 ± 57.7a,b
115.9 ± 68.2a,c
HDL cholesterol (mg/dl)
45.5 ± 12.3b,c
51.0 ± 12.6a,b
48.5 ± 12.4a,c
88.9 ± 8.8
78.6 ± 8.1
81.2 ± 8.2
The rate of AO according to SC
Prevalence of abdominal obesity stratified by gender and constitution
ORs for AO before and after adjustment
Adjusted odds ratios and 95% CI for abdominal obesity according to constitution
OR (95% CI)
OR (95% CI)
OR (95% CI)
SE Type:TE Type
SY Type:TE Type
SE Type:TE Type
SY Type:TE Type
The result revealed that the TE type was associated with increased AO prevalence compared with SE and SY types in males (model 1, OR 10.19; 95% CI 6.5–15.96, p < 0.001 and OR 3.59; 95% CI 2.63–4.9, p < 0.001, respectively). The TE type remained significantly associated with increased AO prevalence after adjusting for age and BMI (model 2, OR 1.77; 95% CI 1.01-3.16, p = 0.045 and OR 1.72; 95% CI 1.17-2.53, p = 0.006, respectively) and age, BMI, hypertension, DM, hypertriglyceridemia, and low HDL cholesterol (model 3, OR 1.79; 95% CI 1.02-3.15, p = 0.044 and OR 1.74; 95% CI 1.18–2.58, p = 0.006, respectively).
We also found a similar trend in females. The TE type was associated with increased AO prevalence compared with SE and SY types (model 1, OR 7.79; 95% CI 5.84–10.4, p < 0.001 and OR 4.99; 95% CI 3.79–6.56, p < 0.001, respectively), and the TE type remained significantly associated with increased AO prevalence after adjusting for age and BMI (model 2, OR 1.65; 95% CI 1.13–2.41, p = 0.01 and OR 1.9; 95% CI 1.35–2.7, p < 0.001, respectively) and age, BMI, hypertension, DM, hypertriglyceridemia, and low HDL cholesterol (model 3, OR 1.51; 95% CI 1.03-2.23, p = 0.037 and OR 1.88; 95% CI 1.32–2.68, p < 0.001, respectively).
Several studies have suggested that the SC could be associated with some chronic diseases, and it has been recognized as an independent risk factor [19–23]. Recently, a gene-level study also revealed that SC was associated with AO . In this cross-sectional study, we aimed to determine whether the SC could be a risk factor for AO among Koreans.
This study suggested that SC may be a significant and independent risk factor of AO. Specifically, the TE type was associated with increased AO prevalence compared with the SE and SY types in males (OR 1.79; 95% CI 1.02–3.15, and OR 1.74; 95% CI 1.18–2.58, respectively) and females (OR 1.51; 95% CI 1.03–2.23, and OR 1.88; 95% CI 1.32-2.68, respectively), even after adjusting for age, BMI, hypertension, DM, hypertriglyceridemia, and low HDL cholesterol. This result means that the TE type could be more susceptible to AO than other types, which is similar to the trend found for hypertension, DM, and metabolic syndrome, which are associated with SC [19–23].
The results revealed that the WC was different according to SC type, and the TE type had the largest WC, which was similar to other characteristics. The rates of AO were different among SC types, and the rate of AO in the TE type was higher than in other types in both genders. However, because the comparatively larger WC of the TE type may be caused by a relatively higher BMI, age, and several chronic diseases , it is necessary to explain the pure influence of SC itself. Accordingly, we calculated ORs for AO with a logistic regression analysis model after adjusting for the influence of potential variables. The multiple logistic regression analysis showed that large differences in the OR between the TE type and other types prior to adjusting for the potential variables (model 1) were still significant in models 2 and 3. Furthermore, this trend was similar in both males and females.
This trend supports the hypothesis that people classified as TE type might have a bigger belly and a higher prevalence rate for AO compared with other types, even if each type has similar physical characteristics. This finding might also be indirect evidence for SCM, which suggests that body shape could develop differently from one constitution to another.
In this study, we tried to enroll a representative Korean population from nationwide centers. We also minimized measurement error by following SOPs  and blood testing error by utilizing a qualified institution.
The prevalence rates of AO in this study were relatively high compared with a previous study conducted by the Korean government . For this reason, we assumed that the average age in this study was relatively higher.
Our study has several limitations. Previously, a large Korean family study suggested a significant association of chromosomes 8q11.22-23 and 11q22.1-3 with SC , and another study found that SC was associated with AO at the genetic level . Family surveys and gene-level studies could be a good method to demonstrate whether SC is an inherent risk factor for AO. However, because our study had a cross-sectional design, we could not analyze the association between inherent SC and AO. In addition, we did not control for environmental factors, such as meals, lifestyle, and exercise habits, which are acquired risk factors for AO.
We believe that further studies on not only a direct comparison between constitutions considering acquired environmental factors for AO but also on inherent family SC are needed.
This study suggested that SC, especially the TE type, might be significantly and independently associated with AO. This finding reveals that SC should be considered a risk factor in predicting AO.
This research was supported by the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2006–2005175) and Korea Institution of Oriental Medicine (KIOM) grant funded by the Korean government (MEST) (No. K13070).
- Haslam DW, James WP: Obesity. Lance. 2005, 366 (9492): 1197-1209. 10.1016/S0140-6736(05)67483-1.View ArticleGoogle Scholar
- Sim KW, Lee SH, Lee HS: The relationship between body mass index and morbidity in Korea. Korean J Obesity. 2001, 10 (2): 147-155.Google Scholar
- Kannel WB, Adrienne Cupples L, Ramaswami R, Stokes J, Kreger BE, Higgins M: Regional obesity and risk of cardiovascular disease; the Framingham Study. J Clin Epidemiol. 1991, 44 (2): 183-190. 10.1016/0895-4356(91)90265-B.View ArticlePubMedGoogle Scholar
- Bouchard C, Bray GA, Hubbard VS: Basic and clinical aspects of regional fat distribution. Am J Clin Nutr. 1990, 52 (5): 946-PubMedGoogle Scholar
- Prineas RJ, Folsom AR, Kaye SA: Central adiposity and increased risk of coronary artery disease mortality in older women. Ann Epidemiol. 1993, 3 (1): 35-41.View ArticlePubMedGoogle Scholar
- Detection EPO: Evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001, 285 (19): 2486-2497. 10.1001/jama.285.19.2486.View ArticleGoogle Scholar
- Fujimoto WY, Bergstrom RW, Boyko EJ, Leonetti DL, Newell--Morris LL, Wahl PW: Susceptibility to development of central adiposity among populations. Obes Res. 2012, 3 (Suppl 2): 179-186.Google Scholar
- WHO: Obesity: preventing and managing the global epidemic. World Health Organization technical report series no. 894. 2000, Geneva; Switzerland: World Health OrganizationGoogle Scholar
- Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC: Diagnosis and management of the metabolic syndrome. Circulation. 2005, 112 (17): 2735-2752. 10.1161/CIRCULATIONAHA.105.169404.View ArticlePubMedGoogle Scholar
- WHO: 2008–2013 action plan for the global strategy for the prevention and control of noncommunicable diseases. 2008, Geneva; Switzerland: World Health Organization, 42-Google Scholar
- Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ: Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr. 2002, 76 (5): 911-922.PubMedGoogle Scholar
- Perez-Pozo S, Schold J, Nakagawa T, Sanchez-Lozada L, Johnson R, Lillo JL: Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes. 2009, 34 (3): 454-461.View ArticleGoogle Scholar
- Choi ME: The not-so-sweet side of fructose. J Am Soc Nephrol. 2009, 20 (3): 457-459. 10.1681/ASN.2009010104.View ArticlePubMedGoogle Scholar
- Rosmond R, Bouchard C, Björntorp P: 5-HT2A receptor gene promoter polymorphism in relation to abdominal obesity and cortisol. Obes Res. 2012, 10 (7): 585-589.View ArticleGoogle Scholar
- Rosmond R, Chagnon YC, Holm G, Chagnon M, Pérusse L, Lindell K, Carlsson B, Bouchard C, Björntorp P: A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes Res. 2012, 8 (3): 211-218.View ArticleGoogle Scholar
- Lee JM: Longevity and life preservation in oriental medicine (東醫壽世保元). 1996, Seoul, Korea: Kyung Hee Univ. PressGoogle Scholar
- Kim JY, Pham DD: Sasang constitutional medicine as a holistic tailored medicine. Evid-Based Complementary Altern Med. 2009, 6 (Suppl 1): 11-19.View ArticleGoogle Scholar
- Shim EB, Lee S, Kim JY, Earm YE: Physiome and sasang constitutional medicine. J Physiol Sci. 2008, 58 (7): 433-440. 10.2170/physiolsci.RV004208.View ArticlePubMedGoogle Scholar
- Lee T, Lee S, Choe B, Song I: A study on the prevalences of chronic diseases according to Sasang constitution at a health examination center. J Sasang Constitut Med. 2005, 17 (2): 32-45.Google Scholar
- Lee TG, Koh B, Lee S: Sasang constitution as a risk factor for diabetes mellitus: a cross-sectional study. Evid-Based Complementary Altern Med. 2009, 6 (1): 99-103. 10.1093/ecam/nem063.View ArticleGoogle Scholar
- Lee J, Lee E, Yoo J, Kim Y, Koh B: The sasang constitutional types can act as a risk factor for hypertension. Clin Exp Hypertens. 2011, 33 (8): 525-532. 10.3109/10641963.2011.561901.View ArticlePubMedGoogle Scholar
- Choi K, Lee J, Yoo J, Lee E, Koh B: Sasang constitutional types can act as a risk factor for insulin resistance. Diabetes Res Clin Pract. 2011, 91 (3): e57-e60. 10.1016/j.diabres.2010.11.017.View ArticlePubMedGoogle Scholar
- Song KH, Yu SG, Kim JY: Prevalence of metabolic syndrome according to Sasang constitutional medicine in Korean subjects. Evid-Based Complementary Altern Med. 2012, 2012: 646794-Google Scholar
- Lee MK, Jang ES, Sohn HY, Park JY, Koh BH, Sung J, Kim JI, Kim JY, Seo JS: Investigation of genetic evidence for Sasang constitution types in South Korea. Genomics & Informatics. 2009, 7 (2): 107-110. 10.5808/GI.2009.7.2.107.View ArticleGoogle Scholar
- Won HH, Lee S, Jang E, Kim KK, Park YK, Kim YJ, Kim YS, Kim BY, Kim JY, Kim JW: A genome-wide scan for the sasang constitution in a korean family suggests significant linkage at chromosomes 8q11. 22–23 and 11q22. 1–3. J Altern Complement Med. 2009, 15 (7): 765-769. 10.1089/acm.2009.0067.View ArticlePubMedGoogle Scholar
- Jang E, Kim JY, Lee H, Kim H, Baek Y, Lee S: A Study on the reliability of Sasang constitutional body trunk measurement. Evid-Based Complementary Altern Med. 2011, 2012: 604842-Google Scholar
- Song KH, Yu SG, Cha S, Kim JY: Association of the apolipoprotein A5 gene − 1131 T > C polymorphism with serum lipids in Korean subjects: impact of Sasang constitution. Evid-Based Complementary Altern Med. 2011, 2012: 598394-Google Scholar
- Després JP, Lemieux I: Abdominal obesity and metabolic syndrome. Nature. 2006, 444 (7121): 881-887. 10.1038/nature05488.View ArticlePubMedGoogle Scholar
- Sánchez-Castillo CP, Velásquez-Monroy O, Lara-Esqueda A, Berber A, Sepulveda J, Tapia-Conyer R, T James WP: Diabetes and hypertension increases in a society with abdominal obesity: results of the Mexican National Health Survey 2000. Public Health Nutr. 2005, 8 (01): 53-60. 10.1079/PHN2005659.View ArticlePubMedGoogle Scholar
- KIOM: Development of Diagnostic and Herbal Drug System based on Traditional Constitutional Korean Medicine. 2007, Daejeon; Korea: Korea Institute of Oriental MedicineGoogle Scholar
- Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT: Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003, 42 (6): 1206-1252. 10.1161/01.HYP.0000107251.49515.c2.View ArticlePubMedGoogle Scholar
- Association AD: Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010, 33 (Suppl 1): 62-69.View ArticleGoogle Scholar
- WHO: The Asia-Pacific perspective: redefining obesity and its treatment. 2000, Geneva; Switzerland: World Health OrganizationGoogle Scholar
- Cha S, Koo I, Park BL, Jeong S, Choi SM, Kim KS, Shin HD, Kim JY: Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evid-Based Complementary Altern Med. 2011, 2011: 10.1093/ecam/nep1162.Google Scholar
- Kim JW, Jeon SH, Sull YK, Kim KK, Lee EJ: A study on the body shape classified by Sasang constitutions and gender using physical measurements. J Sasang Constitut Med. 2006, 18 (1): 54-61.Google Scholar
- KCDC: The Third Korea National Health and Nutrition Examination Survey (KNHANES III) 2005 Health Examination. 2006, Gwacheon; Korea: Korea Centers for Disease Control and PreventionGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/72/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.