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Anti-proliferative effect of methanolic extract of Gracilaria tenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress

  • Chi-Chen Yeh1,
  • Jing-Iong Yang2,
  • Jin-Ching Lee3,
  • Chao-Neng Tseng1, 4,
  • Ya-Ching Chan4,
  • You-Cheng Hseu5,
  • Jen-Yang Tang6, 7,
  • Li-Yeh Chuang8,
  • Hurng-Wern Huang9,
  • Fang-Rong Chang1Email author and
  • Hsueh-Wei Chang1, 4, 10Email author
BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201212:142

DOI: 10.1186/1472-6882-12-142

Received: 21 February 2012

Accepted: 23 August 2012

Published: 31 August 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
21 Feb 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
18 Mar 2012 Reviewed Reviewer Report - Karl Kingsley
27 Mar 2012 Reviewed Reviewer Report - Natalia Aptsiauri
4 Apr 2012 Reviewed Reviewer Report - Sarangapani Sreelatha
4 May 2012 Author responded Author comments - Hsueh-Wei Chang
Resubmission - Version 3
4 May 2012 Submitted Manuscript version 3
1 Jun 2012 Reviewed Reviewer Report - Karl Kingsley
6 Jun 2012 Reviewed Reviewer Report - Natalia Aptsiauri
13 Jun 2012 Reviewed Reviewer Report - Sarangapani Sreelatha
10 Aug 2012 Author responded Author comments - Hsueh-Wei Chang
Resubmission - Version 4
10 Aug 2012 Submitted Manuscript version 4
20 Aug 2012 Author responded Author comments - Hsueh-Wei Chang
Resubmission - Version 5
20 Aug 2012 Submitted Manuscript version 5
Publishing
23 Aug 2012 Editorially accepted
31 Aug 2012 Article published 10.1186/1472-6882-12-142

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University
(2)
Department of Seafood Science, National Kaohsiung Marine University
(3)
Department of Biotechnology, Kaohsiung Medical University
(4)
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University
(5)
Department of Cosmeceutics, College of Pharmacy, China Medical University
(6)
Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University
(7)
Department of Radiation Oncology, Kaohsiung Medical University Hospital
(8)
Department of Chemical Engineering, I-Shou University
(9)
Institute of Biomedical Science, National Sun Yat-Sen University
(10)
Center of Excellence for Environmental Medicine, Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University

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