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Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom

  • Rafael M Ximenes1,
  • Renata S Alves2,
  • Ticiana P Pereira2,
  • Renata M Araújo3, 4,
  • Edilberto R Silveira4,
  • Marcelo M Rabello5,
  • Marcelo Z Hernandes5,
  • Veronica C G Soares6, 7,
  • Daniel Bristot7,
  • Camila L Pires7,
  • Daniela O Toyama8,
  • Henrique H Gaeta7,
  • Helena S A Monteiro1 and
  • Marcos H Toyama7Email author
BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201212:139

DOI: 10.1186/1472-6882-12-139

Received: 16 April 2012

Accepted: 16 August 2012

Published: 27 August 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
16 Apr 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
20 Apr 2012 Author responded Author comments - Marcos Toyama
Resubmission - Version 3
20 Apr 2012 Submitted Manuscript version 3
18 May 2012 Reviewed Reviewer Report - Man Hee Rhee
18 Jun 2012 Reviewed Reviewer Report - Sarada Tetali
26 Jul 2012 Author responded Author comments - Marcos Toyama
Resubmission - Version 4
26 Jul 2012 Submitted Manuscript version 4
Publishing
16 Aug 2012 Editorially accepted
27 Aug 2012 Article published 10.1186/1472-6882-12-139

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Physiology and Pharmacology, Federal University of Ceará
(2)
Department of Clinical and Toxicological Analysis, Federal University of Ceará, UFC
(3)
Department of Chemistry, Federal University of Rio Grande do Norte, UFRN
(4)
Department of Organic and Inorganic Chemistry, Federal University of Ceará, UFC
(5)
Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE
(6)
Department of Biochemistry, Institute of Biology, State University of Campinas, UNICAMP
(7)
São Vicente Unit, State University of São Paulo Júlio Mesquita Filho, UNESP
(8)
Center of Biological and Health Sciences, Mackenzie Presbyterian University

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