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A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines

  • Christian Freise1,
  • Martin Ruehl1,
  • Ulrike Erben1,
  • Ulf Neumann2, 3,
  • Daniel Seehofer2,
  • Ki Young Kim4,
  • Wolfram Trowitzsch-Kienast5,
  • Thorsten Stroh1,
  • Martin Zeitz1 and
  • Rajan Somasundaram1Email author
BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201111:39

DOI: 10.1186/1472-6882-11-39

Received: 24 January 2011

Accepted: 12 May 2011

Published: 12 May 2011

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
24 Jan 2011 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
17 Mar 2011 Reviewed Reviewer Report - AR Khuda-Bukhsh
5 Apr 2011 Reviewed Reviewer Report - Akiko Kojima-Yuasa
18 Apr 2011 Author responded Author comments - Christian Freise
Resubmission - Version 3
18 Apr 2011 Submitted Manuscript version 3
21 Apr 2011 Reviewed Reviewer Report - AR Khuda-Bukhsh
29 Apr 2011 Reviewed Reviewer Report - Akiko Kojima-Yuasa
9 May 2011 Author responded Author comments - Christian Freise
Resubmission - Version 4
9 May 2011 Submitted Manuscript version 4
Publishing
12 May 2011 Editorially accepted
12 May 2011 Article published 10.1186/1472-6882-11-39

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin
(2)
Department of General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum
(3)
Department of Surgery, University Hospital Aachen
(4)
Faculty of Beauty Design, Human Environmental Science College, Wonkwang University
(5)
Department of Chemical and Pharmaceutical Engineering, Beuth Hochschule für Technik

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